Rat liver glutamine transaminase acts on y-glutamyl hydrazones of a-keto acids to yield the corresponding L-amino acids and 3-hydroxy-tetrahydro-6-pyridazinone-3-carboxyllc acid; the latter compound undergoes nonenzymatic dehydration in acid to yield 1,4,5,6-tetrahydro-6-pyridazinone -3carboxylic acid. L-Amino acid oxidase (snake venom) also catalyzes the formation of 3-hydroxy-tetrahydro-6-pyr...

Synthesis and Antimicrobial Activity of Some 3(2H)-Pyridazinone and 1(2H)-Phthalazinone Derivatives Deniz S. DOĞRUER1,∗, Tijen ÖNKOL, Semiha ÖZKAN, Selda ÖZGEN, M. Fethi ŞAHİN Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, 06330 Etiler, Ankara-TURKEY e-mail: [email protected] Department of Microbiology, Faculty of Pharmacy, Gazi University, 06330 Etiler, ...

The compounds, 3,6-dimethoxypyridazine, l,2-dimethyl3,6(1H,2H)-pyridazinedione, and 6-methoxy-2-methyl-3(2H)pyridazinone, were prepared by using reported preparations. Their photochemistry was investigated and compared to the thermal chemistry and photochemistry of maleic hydrazide. , I' 1.!. t, 1, 1 I, I : vii

methyl indole derivative of some 6-aryl-4,5-dihydropyridazin-3(2h)-ones (3a-e) were synthesized by mannich reaction and evaluated as anticonvulsant against mes (50ma, for 2sec), inh (250mg/kg), scptz (80mg/kg) and str (3mg/kg) induced convulsion methods at 50 mg/kg dose level. all compounds 3a-e were also evaluated as antitubercular agent against m. tuberculosis h37rv by maba method. all compou...

Four pyridazinones (2-5) were synthesized by the reaction of 3-benzoylpropionic acid with the corresponding hydrazines. These pyridazinones were further derivatized with appropriate aromatic aldehydes in the presence of piperidine to obtain the desired compounds (6-13). The chemical structures of the synthesized pyridazinones were elucidated on the basis of their spectral analysis (IR, 1H-NMR, ...