SCY-078 (MK-3118) is a novel, semisynthetic derivative of enfumafungin and represents the first compound of the triterpene class of antifungals. SCY-078 exhibits potent inhibition of β-(1,3)-d-glucan synthesis, an essential cell wall component of many pathogenic fungi, including Candida spp. and Aspergillus spp. SCY-078 is currently in phase 2 clinical development for the treatment of invasive ...

Candidaauris, a new multidrug-resistant Candida spp. which is associated with invasive infection and high rates of mortality, has recently emerged. Here, we determined the virulence factors (germination, adherence, biofilm formation, phospholipase and proteinase production) of 16 C. auris isolates and their susceptibilities to 11 drugs belonging to different antifungal classes, including a nove...

Delayed posterior wall (PW) peak in the detection of PW asynergy was studied by M-mode echocardiography in 53 patients with angiographically proven PW aneurysm, hypokinesis and normal PW. The timing of the PW peak was evaluated by the intervals between (1) the aortic valve closure (Ac) and the PW peak, and (2) the R wave of the electrocardiogram and the PW peak (R-peak). The PW excursion predic...

Clostridium difficile infections (CDI) have emerged as a major cause of healthcare associated disease, and recent epidemiological evidence also suggests an important role in community-acquired diarrhea. This increase is associated with specific types, especially PCR ribotypes 027 and 078, which are sometimes referred to as "hypervirulent". Over the past years major advances have been made in ou...

This document specifies a mechanism to signal Pseudowire (PW) status messages using a PW associated channel (ACh). Such a mechanism is suitable for use where no PW dynamic control plane exits, known as static PWs, or where a Terminating Provider Edge (T-PE) needs to send a PW status message directly to a far-end T-PE. The mechanism allows PW Operations, Administration, and Maintenance (OAM) mes...

Pseudowire signaling requires that the Pseudowire Type (PW Type) be identical in both directions. For certain applications the configuration of the PW Type is most easily accomplished by configuring this information at just one PW endpoint. In any form of LDP-based signaling, each PW endpoint must initiate the creation of a unidirectional LSP. In order to allow the initiation of these two LSPs ...

This document describes a framework comprised of a number of scenarios and associated requirements for pseudowire (PW) redundancy. A set of redundant PWs is configured between provider edge (PE) nodes in single-segment PW applications or between terminating PE (T-PE) nodes in multi-segment PW applications. In order for the PE/T-PE nodes to indicate the preferred PW to use for forwarding PW pack...

This document describes how to connect pseudowires (PWs) between different Packet Switched Network (PSN) domains or between two or more distinct PW control plane domains, where a control plane domain uses a common control plane protocol or instance of that protocol for a given PW. The different PW control plane domains may belong to independent autonomous systems, or the PSN technology is heter...

TO THE EDITOR—We thank Walker et al for their interest in our work [1]. Our study found no evidence of difference in clinical severity of Clostridium difficile infection (CDI) between patients infected with ribotype 027/078 strains compared with others, when adjusted for other co-variates [2]. Adjustment for factors on the hypothesized causal pathway between exposure (ribotype) and outcome (sev...