This study evaluated the biocompatibility of mineral trioxide aggregate (MTA) after direct capping of exposed pulp tissue in dog's teeth. Class I cavities were prepared in 26 teeth from 3 adult dogs. MTA was applied over the exposed pulp in 13 teeth and paste of calcium hydroxide plus distilled water (control) was applied in the remaining 13 teeth. After 90 days, the animals were killed; the ma...

In order to find whether presynaptic inhibition of tooth pulp afferents is enhanced in any phase of sleep or wakefulness, the orthodromic mass response of the trigeminal nucleus to electrical stimulation of the ipsilateral tooth pulp and the antidromic mass response of the tooth pulp to stimulation of the trigeminal nucleus were recorded in the cat. Both responses were stable in amplitude durin...

OBJECTIVE The purpose of this study was to investigate the pulpal response of dogs' teeth after pulpotomy and direct pulp protection with MTA Angelus, ProRoot, Portland cement and white Portland cement. STUDY DESIGN Seventy-six teeth were treated with these materials. One hundred twenty days after treatment, the animals were sacrificed and the specimens removed and prepared for histological a...

( o ( a p bstract his study evaluated the histomorphologic response of uman dental pulps capped with mineral trioxide agregate (MTA) and Ca(OH)2 cement (CH). Pulp expoures were performed on the occlusal floor of 40 human ermanent premolars. After that, the pulp was capped ither with CH or MTA and restored with composite esin. After 30 and 60 days, teeth were extracted and rocessed for histologi...

INTRODUCTION The purpose of this study was to assess the accuracy of sensibility tests by correlating it with histologic pulp condition. METHODS AND MATERIALS Assessment of clinical signs and symptoms were performed on 65 permanent teeth that were scheduled to be extracted for periodontal, prosthodontic or orthodontic reasons. The normal pulp and reversible pulpitis were considered as treatab...

One of the causes of dental pulpitis is lipopolysaccharide- (LPS-) induced inflammatory response. Following pulp tissue inflammation, odontoblasts, dental pulp cells (DPCs), and dental pulp stem cells (DPSCs) will activate and repair damaged tissue to maintain homeostasis. However, when LPS infection is too serious, dental repair is impossible and disease may progress to irreversible pulpitis. ...

The penetration of cariogenic oral bacteria into enamel and dentin during the caries process triggers an immune/inflammatory response in the underlying pulp tissue, the reduction of which is considered a prerequisite to dentinogenesis-based pulp regeneration. If the role of odontoblasts in dentin formation is well known, their involvement in the antibacterial response of the dental pulp to cari...

INTRODUCTION Biodentine is a new bioactive cement that is similar to the widely used mineral trioxide aggregate (MTA). It has dentin-like mechanical properties, which may be considered a suitable material for clinical indications of dentin-pulp complex regeneration such as direct pulp capping. The purpose of the present study was to compare the response of the pulp-dentin complex in human teeth...

Inflammatory response in the dental pulp can alter the collagen matrix formation by dental pulp stem cells and lead to a delay or poor healing of the pulp. This inflammatory response is mediated by cytokines, including interleukin-1β and tumor necrosis factor-α. In this study, it is hypothesized that suppressing the actions of these inflammatory cytokines by knocking down the activity of transc...