Polyunsaturated omega-3 fatty acids (omega-3 PUFA) are important components of cell membrane affecting its function and their deficiency is deleterious to health. We have previously shown that spontaneously hypertensive rats (SHR) are prone to life-threatening arrhythmias that are reduced by omega-3 PUFA intake. Purpose of this study was to explore plasma and red blood cells (RBC) profile of om...

Vitamin E (α-tocopherol) is recognised as a key essential lipophilic antioxidant in humans protecting lipoproteins, PUFA, cellular and intra-cellular membranes from damage. The aim of this review was to evaluate the relevant published data about vitamin E requirements in relation to dietary PUFA intake. Evidence in animals and humans indicates a minimal basal requirement of 4-5 mg/d of RRR-α-to...

BACKGROUND The optimal method for conducting omega (n-)3 polyunsaturated fatty acid (PUFA) supplementation trials in children is unknown. AIM To assess the impact of n-3 and n-6 PUFA intake from the background diet on plasma levels of n-3 and n-6 PUFA in children aged 0-3 years, with and without n-3 supplementation. METHODS Subjects were randomised antenatally to receive either n-3 PUFA sup...

Indian Asians living in the UK have a 50% higher CHD mortality rate compared with the indigenous Caucasian population, which cannot be attributed to traditional risk factors. Instead, features of the metabolic syndrome, including raised plasma triacylglycerol, reduced HDL-cholesterol (HDL-C) and an increased proportion of small dense LDL particles, together with insulin resistance and central o...

Organisms at the base of stream food webs are typically poor in long-chain polyunsaturated fatty acids (LC-PUFA), especially docosahexaenoic acid (DHA), whereas consumers higher trophic levels often rich LC-PUFA. For example, fish tissues, brain, DHA-rich. This obvious mismatch between consumer LC-PUFA and their basal dietary supply may result from selective retention and/or endogenous conversi...

Objectives: To validate the PUFA/pufa index and to assess the prevalence and severity of oral conditions related to untreated dental caries. Methods: Pufa index records the presence of pulpal exposure (P/p), ulceration caused by sharp edges of dislodged tooth fragments (U/u), fistula (F/f) and abscess (A/a) formation in grossly decayed teeth. Results: Good Kappa values shows reliability of the ...

To the Editor: I agree with Kuratko that there is a need for tailored food frequency questionnaires (FFQ), particularly for nutrients that have limited food sources, such as long chain ω-3 polyunsaturated fatty acids (LC ω-3 PUFA). Fish are the best food source of LC ω-3 PUFA, and oily fish such as sardines and Atlantic salmon contain approximately 10 times more LC ω-3 PUFA than lean fish, such...

Many studies have implicated oxygen radicals and lipid peroxidation in various diseases. Polyunsaturated fatty acids (PUFA) are believed to be one of the keys for understanding the damage that can be done to cells by free radicals. Free radical attack on PUFA may result in (1) the loss of PUFA which play important roles in cell membrane structure and as precursors for eicosanoid (prostaglandin ...

Dietary n-3 polyunsaturated fatty acids (PUFA) reduce coronary heart disease (CHD) complications, such as chronic arrhythmia and sudden cardiac death. Improved myocardial resistance to ischemia-reperfusion injury results in smaller myocardial infarction, which is a major factor in the occurrence of CHD complications. We hypothesized that a specific dietary fatty acid profile (low in saturated a...