Aims Precocious puberty is defined as the precocious onset of pubertal manifestations. The cause of precocious puberty is unknown despite numerous attempts to find it. Despite most precocious puberty is sporadic disease, some patients have familial tendency. Recently specific gene mutation has proven to cause precocious puberty and the existence of familial precocious puberty is emerging. This ...

Puberty is a series of physical development and sexual maturation that aims to achieved reproductive capacity. The hypothalamic-pituitary-gonadal (HPG) axis has an important role in the normal process puberty. Disruption HPG causes hormonal disturbances, one which hypogonadotropic hypogonadism, associated with delayed Hormonal disorders can also cause various problems besides system, such as mu...

background: early puberty is a common worldwide problem. different parameters as genetics, metabolic diseases, obesity, as well as environmental factors may affect the age of puberty. this systematic review aims to survey the related literature on the effects of environmental pollutants and especially organohalogens and phthalates on early puberty. materials and methods: a systematic review of ...

OBJECTIVE Precocious puberty is of concern because of the underlying disorders, the short adult stature, and the psychosocial difficulties. This study was carried out in order to evaluate the characteristics of children referred to pediatric endocrinology clinic with diagnosis of precocious puberty. METHODS In a cross-sectional study between February 2007 and September 2009, all of the childr...

mental health problems including emotional and behavioral problems during puberty may be under influence of different risk factors including cultures, living in urban or rural areas and ethnic factors which may vary between different countries. the main aim of this study is to investigate the profile of emotional and behavioral problems and the role of factors such as age, stage of puberty, eth...

Excitatory amino acids, glutamate in particular, have a marked stimulatory effect on the reproductive axis, particularly at puberty. Glutamate, N-methyl-D-aspartate (NMDA), and kainate stimulate gonadotropin-releasing hormone (GnRH) secretion in immature mammals and NMDA receptor stimulation results in precocious puberty in rats and monkeys. Puberty is characterized by an increased sensitivity ...

BACKGROUND It is well known that excess adiposity during childhood may influence pubertal development. However, the extent to which body compositions vary in throughout puberty in boys and girls is currently unknown. The aim of this study was to investigate whether obesity and body compositions correlate with the timing of puberty in boys and girls. METHODS By random cluster sampling, our stu...

The study comprises observations in 464 Swedish Yorkshire pigs at puberty and after the first weaning. The aim was to study relationships between age at puberty and weaning to estrus interval and between estrus signs at puberty and after the first weaning. The estrus signs were checked, and blood samples for progesterone determination were drawn regularly around puberty and after the first wean...