Among other effects, post-translational modifications (PTMs) have been shown to exert their function via the modulation of protein-protein interactions. For twelve different main PTM-types and associated subtypes and across 9 diverse species, we investigated whether particular PTM-types are associated with proteins with specific and possibly "strategic" placements in the network of all protein ...

Recent reports suggest that tidal stretches do not cause significant and sustainable dilation of constricted intact airways ex vivo. To better understand the underlying mechanisms, we aimed to map the physiological stretch-induced molecular changes related to cytoskeletal (CSK) structure and contractile force generation through integrin receptors. Using ultrasound, we measured airway constricti...

The emergence of efficient fragmentation methods such as electron capture dissociation (ECD) and electron transfer dissociation (ETD) provides the opportunity for detailed structural characterization of heavily covalently modified large peptides and small proteins such as intact histones. Even with effective gas phase ion isolation so that a single molecular precursor ion is selected, the MSMS ...

Pretibial myxedema (PTM) is usually a late manifestation of Graves' disease and is relatively rare. The elephantiasis nostras variant comprises less than one percent of patient with pretibial myxedema. We report two cases of elephantiasic PTM and review the literature regarding its treatment. Therapy of the elephantiasic variant of PTM remains suboptimal at present. ( J Intern Med Taiwan 2004; ...

Androgens are essential for normal spermatogenesis and male fertility, but how androgens exert this effect remains uncertain. Androgen receptors (ARs) are expressed in several testicular cell types, but continuing uncertainty exists over which cell type mediates androgen control of spermatogenesis. Androgen signaling via Sertoli cells (SCs) is essential for complete spermatogenesis, but the rol...

In this paper, we first address the measurements to improve classification accuracy for parametric trajectory modeling (PTM), exploring the effect of context -dependent information, prosody knowledge (pitch, duration) and derivative features (to depict speech dynamics further besides the advantage of PTM on this aspect). Experiment shows 61.585% error reduction with these techniques. We then us...

Parallel Turing machines (Ptm) can be viewed as a generalization of cellular au-tomata (Ca) where an additional measure called processor complexity can be deened which indicates the \amount of parallelism" used. In this paper Ptm are investigated with respect to their power as recognizers of formal languages. A combinatorial approach as well as diagonalization are used to obtain hierarchies of ...

Owing to the importance of the post-translational modifications (PTMs) of proteins in regulating biological processes, the dbPTM (http://dbPTM.mbc.nctu.edu.tw/) was developed as a comprehensive database of experimentally verified PTMs from several databases with annotations of potential PTMs for all UniProtKB protein entries. For this 10th anniversary of dbPTM, the updated resource provides not...

Ag receptor loci poised for V(D)J rearrangement undergo germline transcription (GT) of unrearranged genes, and the accessible gene segments are associated with posttranslational modifications (PTM) on histones. In this study, we performed a comprehensive analysis of the dynamic changes of four PTM throughout B and T cell differentiation in freshly isolated ex vivo cells. Methylation of lysines ...

Interpreting the impact of human genome variation on phenotype is challenging. The functional effect of protein-coding variants is often predicted using sequence conservation and population frequency data, however other factors are likely relevant. We hypothesized that variants in protein post-translational modification (PTM) sites contribute to phenotype variation and disease. We analyzed frac...