We have prepared a viscous bicontinuous microemulsion consisting of water / [20 wt% POE-GIS + 30 wt% PEPTME + 47.5 wt% POE/POP-PDMS + 2.5 wt% OA)] / DMPS system. A pseudoternary phase diagram was constructed for the mixture, and the bicontinuous microemulsion phase was characterized by means of rheometry and freeze-fracture transmission electron microscopy (FF-TEM).

The main purpose of the present investigation is to enhance the solubility and bioavailability of poorly watersoluble atorvastatin calcium (ATR) through the self nanoemulsifying drug delivery system (SNEDDS).The components for self-nanoemulsion were identified by solubility studies and tendency for self-emulsification in various excipients. Sefsol 218, Cremophor RH 40 and Propylene glycol were ...

BACKGROUND The stability of protein drugs remains one of the key hurdles to their success in the market. The aim of the present study was to design a novel nanoemulsion drug-delivery system (NEDDS) that would encapsulate a standard-model protein drug--bovine serum albumin (BSA)--to improve drug stability. METHODS The BSA NEDDS was prepared using a phase-inversion method and pseudoternary phas...

The objective of the present study was to design and develop a microemulsion based transungual drug delivery formulation of ciclopirox olamine using colloidal carrier for treatment of onychomycosis. Capmul PG8 was selected as oil phase due to the high solubility of ciclopirox in it as compared to other oils and Cremophor EL and Transcutol P were used as surfactant and cosurfactant respectively....

The objective of this study was to formulate optimal formulations of microemulsions (MEs) and evaluate their feasibility for delivery of resveratrol into human skin ex vivo. Oil-in-water MEs were formulated using surfactant (S) PEG-8 caprylic/capric glycerides and cosurfactant (CoS) polyglyceryl-6-isostearate. Ethyl oleate was used as an oily phase. MEs were formulated using 5 : 1, 6 : 1, and 7...

delivery of available ciclopirox formulations as nail lacquer, cream, lotion, gel is hindered by the low permeability of human nail plates, and so there is need of repeated dosing for a longer period of time for effective treatment. In the present research work an attempt is made for effective delivery of ciclopirox olamine (CIC) across human nail plates by enahancing the penetration of CIC and...

The objective of this study was to develop an oral microemulsion formulation of the antitumor diterpenoid agent, ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic-acid (henceforth referred to as 5F), to enhance its bioavailability and evaluate its hepatotoxicity. Pseudoternary phase diagrams showed that the optimal microemulsion formulation contained 45% water, 10% castor oil as the oil phase, 15% Cremo...