The Drug Enforcement Administration (DEA) is required, as part of the Methamphetamine Epidemic Elimination Act, to develop annual quotas for the manufacture and importation of ephedrine, pseudoephedrine, and phenylpropanolamine products for legitimate utilization in the U.S. At DEA’s request, IMS Health (IMS) identified an approach for generating estimates of 2005 usage for ephedrine and pseudo...

A 68-year-old man presented with a generalized papular eruption with oedema of the face and the hands, fever and pustulosis in intertriginous areas which had begun 1 day after starting treatment with EuvanolA nasal spray (plant extracts and benzalkonium chloride) and DolirhumA (paracetamol and pseudoephedrine). He has been hospitalized 8 years before for a similar eruption associated with hyper...

Pseudoephedrine is frequently used as a decongestant. Because of concern about the safety of pseudoephedrine in hypertensive patients, a clinical trial was conducted to determine whether blood pressure control was actually affected by this drug in a selected group of patients with hypertension. Twenty-nine patients with controlled, uncomplicated hypertension, who received drug therapy and range...

A Stability indicating reverse phase high performance liquid chromatographic method has been developed for the simultaneous determination of Levocetirizine dihydrochloride and Pseudoephedrine sulfate in pharmaceutical formulation. The mobile phase A consisted of Potassium dihydrogen phosphate Buffer 0.05M and 1-Ocatne sulphonic acid sodium salt 0.25%, pH adjusted to 3.0 with orthophospheric aci...

Factors affecting the performance of polyvinyl chloride based ion selective electrode such as using different cationic exchangers and ionophores as well as sensor fabrication procedures were recently the scope of study by several researchers. This work presents an environment friendly electro-analytical method for the determination of Triprolidine HCl (TRI) and Pseudoephedrine HCl (PSE). A comp...

A mixture of acetaminophen, diphenhydramine hydrochloride and pseudoephedrine hydrochloride is used for the symptomatic treatment of common cold. In this study, a derivative spectrophotometric method based on zero-crossing technique was proposed for simultaneous determination of acetaminophen, diphenhydramine hydrochloride and pseudoephedrine hydrochloride. Determination of these drugs was perf...

This study was designed to optimize a method for the identification and quantification of ephedrines in oral fluid (OF) and for its application to subjects taking different doses of pseudoephedrine. Ephedrines use by athletes is banned by World Anti-Doping Agency (WADA), only "in competition" if their concentration in urine exceeds the cutoff limit. The study aimed to establish if there is a co...

In this chapter, the feasibility of extracting a cationic species with carbon dioxide was examined as well as determining what factors may improve its extractability and why. Pseudoephedrine hydrochloride (Figure 5.1) was chosen as our test analyte. Pseudoephedrine hydrochloride is an active ingredient in many pharmaceutical cold formulations and serves as a nasal decongestant. Hedrick et al. i...

Gastroschisis and small intestinal atresia (SIA) are birth defects that are thought to arise from vascular disruption of fetal mesenteric vessels. Previous studies of gastroschisis have suggested that risk is increased for maternal use of vasoactive over-the-counter medications, including specific analgesics and decongestants. This retrospective study evaluated the relation between maternal use...

a mixture of acetaminophen, diphenhydramine hydrochloride and pseudoephedrine hydrochloride is used for the symptomatic treatment of common cold. in this study, a derivative spectrophotometric method based on zero-crossing technique was proposed for simultaneous determination of acetaminophen, diphenhydramine hydrochloride and pseudoephedrine hydrochloride. determination of these drugs was perf...