introduction: megaloblasc anemia is an uncommon problem in childhood most frequently associated with vitamin deficiency or gastrointesnal disease. the common causes of megaloblasc anemia are vitamin b12 (cobalamin) deficiency and folic acid deficiency. familial selecve malabsorpon of vitamin b12 associated with proteinuria firstly was described by imerslund (1960) and grasbeck et al (1960)...

introduction: deficiency in mu opioid receptor signaling pathway is partially responsible for morphine tolerance. this deficiency may be due to uncoupling of opioid receptors and related g proteins, which in turn, it may be caused by their structural changes such as phosphorylation or by decreasing their abundance. in this study, we tried to investigate the effect of chronic administration of m...

Masawe, A. E. J., and Rwabwogo-Atenyi, J. (1973). Archives of Disease in Childhood, 48, 927. Serum protein and transferrin determinations to distinguish kwashiorkor from iron deficiency anaemia. Serum proteins and serum transferrin levels were studied in 38 African children of whom 10 were normal controls, 18 had severe iron deficiency anaemia, and 10 had kwashiorkor. The results showed that th...

INTRODUCTION Developmental vitamin D (DVD) deficiency is a candidate risk factor for schizophrenia. Animal models have confirmed that DVD deficiency is associated with a range of altered genomic, proteomic, structural and behavioural outcomes in the rat. Because the nucleus accumbens has been implicated in neuropsychiatric disorders, in the current study we examined protein expression in this r...

To identify the proteins induced by Fe deficiency, we have compared the proteins of Fe-sufficient and Fe-deficient barley (Hordeum vulgare L.) roots by two-dimensional polyacrylamide gel electrophoresis. Peptide sequence analysis of induced proteins revealed that formate dehydrogenase (FDH), adenine phosphoribosyltransferase, and the lds3 gene product (for Fe deficiency-specific) increased in F...

Conformational diseases are caused by the aggregation of misfolded proteins. The risk for such pathologies develops years before clinical symptoms appear, and is higher in people with alpha-1 antitrypsin (AAT) polymorphisms. Thousands deficiency (AATD) underdiagnosed. Enemy-aggregating proteins may reside these underdiagnosed AATD patients many a pathology fully develops. In this perspective re...

Iron (Fe) deficiency is a major constraint for plant growth and affects the quality of edible plant parts. To investigate the mechanisms underlying Fe homeostasis in plants, Fe deficiency-induced changes in the protein profile of Arabidopsis (Arabidopsis thaliana) roots were comprehensively analyzed using iTRAQ (Isobaric Tag for Relative and Absolute Quantification) differential liquid chromato...

CD55 and CD59 are glycosylphosphatidylinositol-anchored proteins with regulatory properties on the activating cascades of the complement system. This regulation occurs through inhibition of the C3-convertase formation by CD55, and prevention of the terminal polymerization of the membrane attack complex by CD59. Deficiency in the expression of these proteins can be associated with increased susc...

Vitamin K (VK) is a fat-soluble vitamin whose deficiency disrupts coagulation and may disturb bone and cardiovascular health. However, the scale and systems affected by VK deficiency in pediatric populations remains unclear. We conducted a study of the plasma proteome of 500 Nepalese children 6-8 years of age (male/female ratio = 0.99) to identify proteins associated with VK status. We measured...

Introduction: Megaloblasc anemia is an uncommon problem in childhood most frequently associated with vitamin deficiency or gastrointesnal disease. The common causes of megaloblasc anemia are vitamin B12 (cobalamin) deficiency and folic acid deficiency. Familial selecve malabsorpon of vitamin B12 associated with proteinuria firstly was described by Imerslund (1960) and Grasbeck et al (1960)...