Suppression of Akt (Protein kinase B) has been implicated in schizophrenia, the effect which has been documented to be reversed by tyrosine phosphatase inhibition. T hus, present study has been designed to study the effect of sodium orthovanadate, a tyrosine phosphatase inhibitor, on protracted methionine administration induced schizophrenia like behavior in rats.   Schizophrenia...

Ohioensins F and G (1 and 2), two new benzonaphthoxanthenones, have been isolated from the MeOH extract of Antarctic moss Polytrichastrum alpinum by various chromatographic methods. The structures of these compounds were determined mainly by analysis of NMR spectroscopic data. The known compounds ohioensins A and C (3 and 4) were also obtained. Compounds 1-4 showed potent inhibitory activity ag...

A series of pyrrolo[2,3-c]azepine derivatives was designed, synthesized, and evaluated as a new class of inhibitors against protein tyrosine phosphatase 1B (PTP1B) in vitro. The results demonstrated that compounds bearing a biphenyl moiety were proved to markedly influence the potency of these inhibitors. Particularly, compounds 29, 35 and 36 showed interesting inhibition with IC(50) value of 1...

suppression of akt (protein kinase b) has been implicated in schizophrenia, the effect which has been documented to be reversed by tyrosine phosphatase inhibition. t hus, present study has been designed to study the effect of sodium orthovanadate, a tyrosine phosphatase inhibitor, on protracted methionine administration induced schizophrenia like behavior in rats.   schizophrenia like behavior ...

BACKGROUND The HD-PTP protein has been described as a tumor suppressor candidate and based on its amino acid sequence, categorized as a classical non-transmembrane protein tyrosine phosphatase (PTP). To date, no HD-PTP phosphorylated substrate has been identified and controversial results concerning its catalytic activity have been recently reported. METHODOLOGY AND RESULTS Here we report a r...

Manzamenones A~C (1~3) and E~F (5~6), unique oxylipin metabolites isolated from a marine sponge Plakortis sp., have been found to exhibit inhibitory activity against Tcell protein tyrosine phosphatase (TCPTP). The inhibitory activity of 2 and 5 against TCPTP was 4 times more potent than that against protein tyrosine phosphatase-1B (PTP1B).

Smoking has been linked to male infertility by affecting the sperm epigenome and genome. In this study, we aimed determine possible changes in transcript levels of PGAM5 (the phosphoglycerate mutase family member 5), PTPRN2 (protein tyrosine phosphatase, N2-type receptor), TYRO3 (tyrosine protein kinase receptor) heavy smokers compared non-smokers, investigate their association with fundamental...

BACKGROUND Protein tyrosine phosphatase non-receptor type 1 is a therapeutic target for the type 2 diabetes mellitus. According to the International Diabetes Federation 2015 report, one out of 11 adults suffers from diabetes mellitus globally. OBJECTIVE Current anti-diabetic drugs can cause life-threatening side-effects. The present study proposes a pipeline for the development of effective a...

Protein tyrosine phosphatases regulate physiological processes including growth, differentiation, metabolism and the cell cycle. Together with tyrosine kinases, they control the phosphorylation state of tyrosine residues of signaling proteins. An increased level of protein phosphorylation results in abnormal proliferation and many cancer types show a mutation or deletion of a protein tyrosine p...