The particle sizes of pharmaceutical substances are important for their bioavailability. Bioavailability can be improved by reducing the particle size of the drug. In this study, artemisinin was micronized by the rapid expansion of supercritical solutions (RESS). The particle size of the unprocessed white needle-like artemisinin particles was 30 to 1200 μm. The optimum micronization conditions ...

Supercritical antisolvent micronization (SAS) is a versatile technique that allows the obtainment of different morphologies and dimensions of precipitates, but only in some cases nanoparticles were produced. This work is focused on the selection of the SAS operating conditions to obtain this morphology. A series of experiments on several compounds and different solvents at 40 °C and selected pr...

Trichlorocarbanilide has widely been used in cosmetics and household products, but the extremely low solubility of trichlorocarbanilide in water constrains the development of water-based products. In order to enhance the bioavailability, trichlorocarbanilide were micronized using supercritical fluid. Supercritical carbon dioxide was selected due to relatively low critical temperature and the ra...

OBJECTIVES This single-dose study compares three dehydroepiandrosterone delivery methods (oral crystalline steroid, micronized steroid, and vaginal administration) to ascertain whether physiologic levels of circulating dehydroepiandrosterone and dehydroepiandrosterone sulfate can be obtained while increases in testosterone are minimized. STUDY DESIGN Two randomized, double-blind, placebo-cont...

2 Research method Different methods of coal processing into fuel [1, 6, 12] usually require its intensive comminution. Such situation needs the creation of new technologies for coal micronization [4, 11, 17] that enlarge specific surface of coal micro particles what finally intensifies burning process of such coal dust. Some interesting effects of water-coal mixture ensure waterjetting technolo...