The Hsp70 co-chaperone CHIP has recently gained attention as a regulator of protein turnover. CHIP has now been reported to be a component of the ubiquitination cascade, specifically an E3 ligase. CHIP appears to be part of a system that diverts incorrectly folded proteins from chaperones to the proteasome.

Background: Skeletal muscle mass, which is regulated by a balance between muscle protein synthesis and degradation, is an important factor for movement to meet everyday needs, especially in pathological conditions and aging. The purpose of the present investigation was to compare the alterations of the gene expression involved in muscle protein synthesis and degradation signaling pathways induc...

current ruminant feeding systems depend on knowledge of the composition of feeds and the rate and extent of degradation of feed organic matter (om) and crude protein (cp) in the rumen. the effect of storage and preparation of samples on in vitro gas production and fermentation characteristics of two common forage species, namely alfalfa and ryegrass werestudied. samples were prepared as fresh (...

the present study was carried out to determine the nutritive value of white varieties of grape pomace (gp) and raisin vitis leaves (rvl), using nylon bags and gas production techniques. tow fistulated whether with average body weight of 45±2 kg were used. the amount of gas produced was measured at 2, 4, 6, 8, 12, 16, 24, 36, 48 and 72 h times and degradation was measured using nylon bags up to ...

Quantitative proteomics captures the steady-state amount of a protein in a cell but does not explain how a change in protein amount is manifest -- whether through a change in synthesis or a change in degradation. If we are to understand the changes in the proteome, we will need to define such processes. In this brief review, strategies for the determination of intracellular protein dynamics on ...