To gain beneficial effects in the management of high-risk prostate cancer, an integrated approach that combines local therapy and androgen deprivation therapy (ADT) was used. We compared biochemical responses between primary cryosurgical ablation of the prostate (CSAP) combined with prolonged ADT and radiation combined with ADT, which is the established modality in high-risk disease. A total of...

The primary study objective was to determine the safety of intraprostatic administration of a replication-competent, oncolytic adenovirus containing a cytosine deaminase (CD)/herpes simplex virus thymidine kinase (HSV-1 TK) fusion gene concomitant with increasing durations of 5-fluorocytosine and valganciclovir prodrug therapy and conventional-dose three-dimensional conformal radiation therapy ...

PurposeIntensity-modulated radiation therapy (IMRT) and laparoscopic or robotic minimally invasive radicalprostatectomy (MIRP) are costlier alternatives to three-dimensional conformal radiation therapy(3D-CRT) and open radical prostatectomy for treating prostate cancer. We assessed temporaltrends in their utilization and their impact on national health care spending.Methods<...

background: the present work aims to study the out-of-field photon calculation accuracy of a commercial treatment planning system (tps), oncentra, for three-dimensional conformal radiotherapy (3d-crt) and intensity modulated radiation therapy (imrt) treatment techniques from elekta synergy medical linear accelerator. materials and methods: accuracy of individual out-of-field dose components was...

Risks of radiation-induced second primary cancer following prostate radiotherapy using 3D-conformal radiotherapy (3D-CRT), intensity-modulated radiotherapy (IMRT), volumetric modulated arc therapy (VMAT), flattening filter free (FFF) and stereotactic ablative radiotherapy (SABR) were evaluated. Prostate plans were created using 10 MV 3D-CRT (78 Gy in 39 fractions) and 6 MV 5-field IMRT (78 Gy i...

PURPOSE To determine the clinical and dosimetric factors that predict prostate-specific antygen (PSA) bouncing following brachytherapy HDR and three-dimensional conformal radiation therapy (3D-CRT) for prostate cancer patients. MATERIAL AND METHODS The evaluated population consisted of 121 prostate cancer patients with a minimum of 5 years of follow-up and at least 6 post-treatment PSA levels...

Background: The present work aims to study the out-of-field photon calculation accuracy of a commercial treatment planning system (TPS), Oncentra, for three-dimensional conformal radiotherapy (3D-CRT) and intensity modulated radiation therapy (IMRT) treatment techniques from Elekta Synergy medical linear accelerator. Materials and Methods: Accuracy of individual out-of-field dose components was...

BACKGROUND The dose distribution to the rectum, delineated as solid organ, rectal wall and rectal surface, in 3D conformal (3D-CRT) and intensity-modulated radiotherapy treatment (IMRT) planning for localized prostate cancer was evaluated. MATERIALS AND METHODS In a retrospective planning study 3-field, 4-field and IMRT treatment plans were analyzed for ten patients with localized prostate ca...

BACKGROUND Although various studies have been conducted on the effects of radiation therapy for prostate cancer, rectal toxicity after radiation therapy for prostate cancer, which is an important late adverse event associated with radiation therapy, has not been sufficiently examined. This study aimed to assess the associations of late rectal disorder (LRD) with dosimetric, anatomic, and clinic...

Technological advances in radiation beam planning and linear accelerator based radiation delivery have led to the development of three dimensional conformal radiation therapy (3D-CRT). The 3D-CRT clinical treatment in our hospital was started in September 1998 and till December 2002, 51 patients with M(0) stage prostate carcinoma were treated. Treatment method consisted of pelvis and leg immobi...