Experimental drugs and/or plant extracts are often dissolved in solvents, including propylene glycol. Nevertheless, there is evidence for psychoactive properties of this alcohol. In this study we found that in the hole-board test 10% propylene glycol did not modify the head-dipping behavior. However, 30% propylene glycol induced an increase in the number of head-dips (46.92 +/- 2.37 compared to...

The main goal of this study was to describe the method of the synthesis of the dodecyl-, tetradecyl-, hexadecyl- and octadecyl-propylene glycol emulsifiers in the presence of selected anionic and nonionic surfactants. Acyl propylene glycol emulsifiers were produced by esterification of propane-1,2-diol (propylene glycol, PG) with C12:0-C18:0 fatty acids in the presence of anionic sodium dodecyl...

OBJECTIVES This study determined the difference in the location of the caries dye staining endpoint of 1% Acid Red dye in propylene glycol versus that of 1% Acid Red dye in polypropylene glycol. METHODS Freshly extracted permanent molar crowns with primary occlusal carious lesions were chisel-split axially to expose the lesion in cross-section on both halves. One half was stained with propyle...

background : propylene glycol (1,2-propanediol, pg) is a commonly used solvent for oral, intravenous, as well as topical pharmaceutical preparations. while pg is generally considered to be safe, it has been known that large intravenous doses given over a short period of time can be toxic. objective: to evaluate the effect of pg in sepsis induced by the bacterial endotoxin lipopolysaccharide (lp...

1285 The world’s neglected tropical diseases (NTDs; Table 1) are becoming less neglected. Many millions of dollars and drugs are now committed to their control, and an open-access journal dedicated to NTDs, PLoS Neglected Tropical Diseases, has been launched (http://www.plosntds.org/). NTDs are characterised by their prevalence in rural areas of low-income countries and fragile states, their te...

of AF performance. that contain EG has been reponed to result in irreversible damage to renal, hepatic, cardiovascular, and central nervous systems, and is a cause of death in household pets and other animals.2-4 It is not known why some animals ingest EGcontaining products. Although there are reports suggesting that the "sweet" taste of EG, and of products containing it, may lead to ingestion ...

A glycol nucleic acid (GNA) with an acyclic propylene glycol phosphodiester backbone forms stable antiparallel duplexes following the Watson-Crick base pairing rules.

Tropical formulations of 5-trifluoromethyl-2'-deoxyuridine (TFT) containing different concentrations of TFT, Azone (Nelson Research and Development, Irvine, Calif.), and propylene glycol were evaluated for their potential efficacy in the treatment of cutaneous herpes simplex virus infections by in vitro studies of TFT penetration through skin and in vivo studies of therapeutic activity against ...

The synthesis of propylene oxide from propylene glycol, a derivative of bio-glycerol, was firstly realized in the presence of alkali-loaded silica catalysts to achieve 44% conversion and 70% selectivity.