Our hypothesis is that leptin release is controlled neurohormonally. Conscious, male rats bearing indwelling, external, jugular catheters were injected with the test drug or 0.9% NaCl (saline), and blood samples were drawn thereafter to measure plasma leptin. Anesthesia decreased plasma leptin concentrations within 10 min to a minimum at 120 min, followed by a rebound at 360 min. Administration...

conclusions the leptin can also be used for the treatment of severe and intractable l. monocytogenes and e. coli infection. results our data demonstrates that leptin is able to induce cd11b expression on neutrophils but this induction is significantly less than l. monocytogenes. indeed, cells treated with leptin had lower amounts of apoptosis compared with untreated cells. the highest amount of...

OBJECTIVE The purpose of this work was to study the direct effect of leptin on LH release by anterior pituitary glands from female rats at the time of spontaneous and steroid-induced LH surge. METHODS LH responsiveness to leptin by pituitaries from rats killed in the afternoon (1500 h) at different stages of the 4-day estrous cycle (diestrus-1: D1; diestrus-2: D2; proestrus; estrus), ovariect...

Emerging evidence has suggested a critical role of leptin in hepatic inflammation and fibrogenesis, however, the precise mechanisms underlying the profibrogenic action of leptin in the liver has not been well elucidated. Therefore, the present study was designed to investigate the expression and functions of leptin receptors (Ob-R) in hepatic sinusoidal cells. Hepatic stellate cells (HSCs), Kup...

BACKGROUND AND PURPOSE Leptin is the major adipose hormone that regulates body weight and energy expenditure by activating leptin receptors in the hypothalamus. Leptin receptors are also present in other cell types, and a potent antiapoptotic effect for leptin has recently been reported. We investigated whether leptin was neuroprotective against ischemic brain injury. METHODS In vitro ischemi...

Lactation in the rat is characterized by the suppression of pulsatile LH secretion, a large increase in food intake, and changes in energy balance due to the metabolic drain of milk production. The change in energy balance may be a major component in altering reproductive function. A number of factors may contribute to changing energy balance of a lactating animal; one is leptin, the product of...

Propranolol regulates angiogenesis in pre-clinical models and reduces distant breast cancer (BC) metastases observational studies. We assessed the feasibility of combining propranolol with neoadjuvant chemotherapy (NAC) patients BC. Women clinical stage II–III BC undergoing NAC [weekly paclitaxel × 12, followed by dose-dense adriamycin/cyclophosphamide (AC) 4] started 20 mg PO BID #1, increased...

background and aims: leptin is a hormone known to control appetite and body weight. the leptin levels in obese animals are always more than animals with normal size. a wide variety of methods have been offered to treat obesity of which herbal therapy is considered as one of these methods. the aim of this study was to investigate the effect of ethanolic extract of asian red ginseng on leptin ser...