The chronic disorder of arterial circulation in the lower extremities due to the atherosclerotic injuries of the femoral-popliteal-tibial arteries was accompanied by the shift of the blood prooxidant-antioxidant balance towards more active free radical oxidation and by a depletion of antioxidant system. After restoring arterial blood flow in the ischemic lower extremities this balance was shift...

During in vitro incubation of rat adipose tissue in a medium containing crystalline serum albumin, a thiobarbituric acid-reacting chromogen (presumably malonaldehyde) appears in the medium, reflecting peroxidation of polyunsaturated fatty acids in the tissue. Albumin which has been dialyzed, treated with EDTA and dialyzed, or subjected to gel filtration shows a markedly decreased ability to sup...

Free transition metal ions oxidize lipids and lipoproteins in vitro; however, recent evidence suggests that free metal ion-independent mechanisms are more likely in vivo. We have shown previously that human ceruloplasmin (Cp), a serum protein containing seven Cu atoms, induces low density lipoprotein oxidation in vitro and that the activity depends on the presence of a single, chelatable Cu ato...

Introduction. Non-steroidal anti-inflammatory drugs (NSAIDs) are ranked first among the world's effective and analgesic with anticipated side effects. That is why prevention of development adverse reactions associated NSAIDs, in particular, those related to their ulcerogenicity, remains a serious global problem. Aims. To characterize mechanisms gastrocytoprotective activity cryopreserved placen...

Objective(s) Comparison of prooxidant-antioxidant balance (PAB) assay with crocin assay. Materials and Methods Twenty eight serum samples were chosen, PAB and the total antioxidant capacity were measured by PAB assay and crocin, respectively, and the correlation of both assays, along with their correlation with other clinical and biochemical parameters, were determined. Results A significa...

Antioxidant-prooxidant imbalance is one of the key mechanisms acute blood loss and ischemic-reperfusion syndrome. Under these conditions, level ceruloplasmin (CP) plays an important role, enhancing antioxidant protection promoting hematopoiesis, exhibiting ferrooxidase action. However, in this case, state antioxidant-prooxidant balance spleen content CP serum studied insufficiently, thus there ...

Chromatography and extraction techniques, and also chemiluminescence have been utilized to develop new rapid and informative tools in the evaluation of long-term properties and environmental effects of polymeric materials. Methods were developed for classification of materials and for early and rapid degradation detection. Degradable polyethylene films were classified on the basis of their inco...

The indolamine melatonin (MEL) is described as an antioxidant and a free radical scavenger. However occasionally, the indoleamine has been reported to increase free radicals with insufficient mechanistic explanation. In an attempt to find a reason for those controversial results, a potential mechanism that explains MEL prooxidant activity is investigated. The current controversy about redox det...

Both ascorbic acid and copper were strong prooxidants in the oxidation of linoleate in a buffered (pH 7.0) aqueous dispersion at 37OC. Minimum concentrations at which catalytic activity was detected were 1.3 X 10-7 M for coppcr and 1.8 X 10-6 M for ascorbic acid. For concentrations up to lop3 M, the increase in rate of oxidation with increase in concentration of catalyst was greater for ascorbi...