STUDY DESIGN A systematic review of randomized and quasi-randomized controlled trials. OBJECTIVES To determine the efficacy of prolotherapy injections in adults with chronic low back pain. SUMMARY OF BACKGROUND DATA Prolotherapy is an injection-based treatment for chronic low back pain. Proponents of prolotherapy suggest that some back pain stems from weakened or damaged ligaments. Repeated...

OBJECTIVES To assess whether prolotherapy, an injection-based therapy, improves elbow pain, grip strength, and extension strength in patients with lateral epicondylosis. SETTING Outpatient Sport Medicine clinic. STUDY DESIGN Double-blind randomized controlled trial. PARTICIPANTS Twenty-four adults with at least 6 months of refractory lateral epicondylosis. INTERVENTION Prolotherapy part...

Barré-Liéou syndrome, or posterior cervical sympathetic syndrome, has symptomatology related to underlying cervical instability. While classified as a rare disease, Barré-Liéou syndrome is likely underdiagnosed. Vertebral instability, occurring after neck ligament injury, affects the function of cervical sympathetic ganglia (located anterior to vertebral bodies). Symptomatology includes neck pa...

BACKGROUND Surgical repair of an atraumatic spontaneous anterior subluxation of the sternoclavicular joint (herein referred to as the "SCJ") is often associated with poor outcome expectations. With traditional treatment, successful conservative therapy usually incorporates major lifestyle alterations. This manuscript discusses a novel approach known as "microperforation prolotherapy". To illust...

Osteoarthritis is the most common degenerative disorder, and one of the major causes of physical disability in adults. Unfortunately many people experience arthroplasty or other major surgeries, in spite of improvements of the conservative options. There is a need for efficient treatment methods in this group of patients. Prolotherapy is one of the simple and safe injection-based complementary ...

Many joint and connective tissue pains defy clear and precise diagnosis. Often patients with various diagnoses for joint, back and neck pain are not cured by traditional treatment regimes appropriate for their “diagnosis”. Based on observations gleaned from treatment responses to Prolotherapy, the author describes and characterizes the Connective Tissue Damage Syndrome. When properly understood...

PURPOSE To present the results of dextrose prolotherapy undertaken for chronic non-responding coccygodynia in 37 patients. METHODS 14 men and 23 women (mean age, 36 years) with chronic coccygodynia not responding to conservative treatment for more than 6 months were included. 27 of them had received local steroid injections. A visual analogue score (VAS) was recorded for all patients before a...

Because the effect of Prolotherapy is to initiate a "healing cascade" which requires inflammation, the patient is advised to avoid anti-inflammatory medications, both over-the-counter and prescription. Aspirin may also interfere with the process to some degree, but if an individual is taking Aspirin to reduce risk of stroke or heart attack, a small amount of Aspirin, such as a "Baby Aspirin" (8...

Methods The study design was a 2-arm non-blinded randomized controlled trial. Group 1 received dextrose prolotherapy and Group 2 was a waitlist control. Nineteen adults seen with at least 3 months of symptomatic CLE in 22 elbows refractory to prior care received ultrasound-guided injections of 20% dextrose-morrhuate sodium (Group 1) solution at baseline, 4, and 8 weeks. Waitlist subjects (Group...