PURPOSE Proliferative vitreoretinopathy (PVR) is an excessive wound-healing process and the major complication in rhegmatogenous retinal detachment. The present study was designed to investigate the expression of keratinocyte transglutaminase (kTgase) in PVR membranes and retinal pigment epithelial (RPE) cells and to evaluate its expression in response to growth factors known to be increased in...

Proliferative vitreoretinopathy (PVR) is the most important complication of rhegmatogenous retinal detachment (RRD) and the main cause of RRD surgery failure. This is a review of recent literature data, which concerns PVR pathogeny and risk factors. The occurrence of pre- and subretinal membranes is a consequence of retinal pigment epithelial cells activation and migration, with concomitant par...

Proliferative vitreoretinopathy (PVR) is the principal cause of failure in retinal detachment (RD) surgery and is characterized by the proliferation of different cell types leading to the formation of cellular membranes on both sides of the retina. These membranes have the capability of contracture resulting in retinal redetachment. Despite marked improvement in vitreoretinal surgical technique...

The experienced retinal surgeon is familiar with the frustrating task of prognosticating and preventing/treating proliferative vitreoretinopathy (PVR) after retinal detachment (RD) surgery. The imperfection of long-described clinical models for predicting PVR leaves the surgeon questioning what underlying predispositions to PVR may exist. Rojas and colleagues provide insight into this question ...

PURPOSE Ablating and cutting vitreoretinal membranes using a 193-nm excimer laser-based microsurgical system. METHODS A 193-nm microsurgical system enables delivery of the beam into a fluid medium to cut preretinal and subretinal membranes. Two patients with proliferative diabetic retinopathy and one patient with proliferative vitreoretinopathy were treated with this new device. RESULTS Gen...

Although attempts were made ot reattach retinas using proliferative vitreoretinopathy by various techniques before the 1970s, it was the development and subsequent refinement of closed-eye, mechanized pars plana vitrectomy that initiated the rapid rise in the surgical success rate. This article presents a personal history of the milestone accomplishments that facilitated the strong possibility ...