The occurrence of pseudotumor cerebri (PTC) and hyperprolactinemia related to a prolactinoma are extremely rare, and the link between these pathologies has not been examined adequately in the post-MRI era. We report a patient with a small intrasellar prolactinoma who also developed PTC. Magnetic resonance venography did not show any evidence of compression of the cavernous or any other sinuses....

Aim Prolactinoma is the most prevalent pituitary tumor that accounts for 40% of all pituitary tumors. It is more prevalent in adults with an estimated prevalence of 100/million, however, it is very rare in childhood and adolescents and clinical spectrums and long-term prognosis remain unclear. The most common clinical manifestations have been known to be growth and pubertal disorders. This stud...

BACKGROUND Bone metabolic disorders in patients with prolactinoma have not been fully characterized. The case presented herein illustrates potential causal associations between prolactinoma and osteopenia, with a reversal of the disorder by treatment with a dopamine agonist. CASE REPORT A 43-year-old male with macro-prolactinoma [PRL 7770 ng/mL] was referred to our hospital. He suffered was o...

Laminin, a major basement membrane component, is important in structural support and cell proliferation and differentiation. Its 19 isoforms are assemblies of α, β, and γ chains, and the α chains (α1-5) determine the isoform characteristics. Although our previous studies showed alterations in α chain expressions during anterior pituitary development, their expressions in pituitary tumors yet to...

Prolactin secreting adenomas are very common and account for 50-60% of all functional pituitary adenomas. Medical history pertaining to reproductive and sexual function initiates the work up for prolactinoma. At the time of initial assessment other pituitary hormones may be evaluated, including growth hormone (GH). Thereafter, patients are treated medically with dopamine agonist, typically with...

INTRODUCTION prolactinomas are pituitary adenomas that express and secrete prolactin. These patients are overweight and the mechanisms are being studied. GOALS assess nutritional and metabolic status of overweight patients with and without hyperprolactinemia caused by prolactinoma and compare them. MATERIALS AND METHODS cross-sectional study, patients with body mass index (BMI) ≥ 25 kg/m2 w...

BACKGROUND Clinical relevance of association of cabergoline use for hyperprolactinemia and cardiac valvulopathy remains unclear. OBJECTIVE The aim of the study was to determine the prevalence of valvular heart abnormalities in patients taking cabergoline for the treatment of prolactinoma and to explore any associations with the cumulative dose of drug used. DESIGN A cross-sectional echocard...

Both It is known that increased body weight is associated with prolactinomas. However, effects of bromocriptine treatment on plasma leptin levels is not clear yet. The aim of this is to evaluate leptin levels before and after bromocripine treatment in patients with prolactinoma. Twenty female patients with prolactinoma and twenty normoprolactinemic, ageand body mass index (BMI)matched healthy f...

BACKGROUND Hyperprolactinemia has been associated with changes in body composition and metabolic abnormalities. Normalization of prolactin (PRL) with dopamine agonists has been found to reverse these abnormalities. This study was designed to assess the anthropometric and metabolic alterations associated with prolactinoma and response of these abnormalities to cabergoline treatment. METHODS In...

This case highlights a prolactinoma in a young male, and its impact on bone health. Osteoporosis has been noted to be an issue in postmenopausal women with prolactinomas. This case shows a similar impact on bone health in a young male resulting in low bone mineral density for age based on Z-score. This case report highlights the possible mechanisms for the bone loss in the setting of prolactino...