In vitro responsiveness of endometrial adenocarcinoma to progestins was evaluated histologically by incubation of tissue fragments in medium containing 10(-6) M medroxyprogesterone acetate. In a series of 19 experiments, formation of sub- and supranuclear vacuoles, which reflects accumulation of glycogen in response to medroxyprogesterone acetate added to the medium, was observed in well-preser...

In vitro responsiveness of endometrial adenocarcinoma to progestins was evaluated histologically by incubation of tissue fragments in medium containing 10~6 M medroxyprogesterone acetate. In a series of 19 experiments, formation of suband supranuclear vacuoles, which reflects accumulation of glycogen in re sponse to medroxyprogesterone acetate added to the medium, was observed in well-preserved...

OBJECTIVES Evidence is accumulating that progestogens may play a crucial role in the development of breast cancer under contraception and hormone therapy in reproductive and menopausal women. Progesterone receptor membrane component 1 (PGRMC1) expressed in breast cancer may be important in tumorigenesis and thus may increase breast cancer risk. The aim of this project was to investigate the inf...

OBJECTIVE Recent report, particularly the Women's Health Initiative, demonstrated that hormone therapy with combined estrogen plus progestin increased the incidence of heart attacks, stroke, blood clots, breast cancer and dementia in women over 65 years old. We investigated the role of synthetic progestins in initiating the adverse events associated with estrogen therapy. METHODS We used a fl...

Svensson, J. 2016. Progestagenic Aquatic Contaminants Act as Potent Androgens in Fish. Experimental Studies in Three-spined Stickleback and Zebrafish. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology 1379. 45 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9587-9. The extensive use of pharmaceuticals and their poor removal by waste...

The effects of some progestins on fish reproduction have been recently reported revealing the hazard of this class of steroidal pharmaceuticals. However, their effects at the central nervous system level have been poorly studied until now. Notwithstanding, progesterone, although still widely considered primarily a sex hormone, is an important agent affecting many central nervous system function...

Background: Endometrial cancer is the most common gynecological malignant neoplasm, which occurs in majority of cases postmenopausally. The current standard treatment surgical - total hysterectomy. However, it may also occur younger patients, who are planning pregnancy and want to choose fertility-sparing treatment. For those patients oral high dose progestin therapy with or without hysteroscop...

1878-3317/$ e see front matter Copyright 2013, Ta http://dx.doi.org/10.1016/j.jecm.2013.02.007 While the estrogen component of oral contraceptive pills is kept at 20e30 mg of ethinyl estradiol/day, attention in the development of new combined contraceptive drugs has been focused on the progestin component. Most of the antiovulatory effects of oral contraceptive pills derive from the action of t...

'Steroid hormones are essential for the growth, differentiation and function of many tissues in both animaIs and humans. It has been established by animal experimentation that modification of the hormonal environment by surgical removal of endocrine glands, by pregnancy or by exogenous administration of steroids can increase or decrease the spontaneous occurrence of tumours or the induction of ...