نتایج جستجو برای: probucol

تعداد نتایج: 552  

1998
Gilles Côté Jean-François Tanguay

Background—We have shown that probucol reduces restenosis after balloon angioplasty. Whether probucol acted via prevention of neointimal formation or improvement in vascular remodeling could not be addressed by angiography and required the use of intravascular ultrasound (IVUS). Methods and Results—Beginning 30 days before angioplasty, 317 patients were randomly assigned to receive probucol, mu...

2012
Xianyi Sha Juan Wu Yanzuo Chen Xiaoling Fang

The objective of our investigation was to design a self-microemulsifying drug-delivery system (SMEDDS) to improve the bioavailability of probucol. SMEDDS was composed of probucol, olive oil, Lauroglycol FCC, Cremophor EL, Tween-80, and PEG-400. Droplet sizes were determined. In vitro release was investigated. Pharmacokinetics and bioavailability of probucol suspension, oil solution, and SMEDDS ...

Journal: :Circulation 2003
Jean-Claude Tardif Jean Grégoire Leonard Schwartz Lawrence Title Louise Laramée François Reeves Jacques Lespérance Martial G Bourassa Philippe L L'Allier Mitchell Glass Jean Lambert Marie-Claude Guertin

BACKGROUND AGI-1067, a metabolically stable modification of probucol, is an equipotent antioxidant to probucol but is pharmacologically distinct. In a multicenter trial, we studied whether AGI-1067 reduces restenosis assessed by intravascular ultrasound (IVUS) after percutaneous coronary intervention (PCI) compared with placebo and probucol used as a positive control. METHODS AND RESULTS Two ...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2005
Ken-ichi Hirano Chiaki Ikegami Ken-ichi Tsujii Zhongyan Zhang Fumihiko Matsuura Yumiko Nakagawa-Toyama Masahiro Koseki Daisaku Masuda Takao Maruyama Iichiro Shimomura Yukihiko Ueda Shizuya Yamashita

OBJECTIVE Scavenger receptor class B type I (SR-BI) is a major receptor for high-density lipoproteins (HDL) in the liver, which is the terminus of reverse cholesterol transport. Overexpression of SR-BI attenuated experimental atherosclerosis in murine models, concomitant with a reduction in plasma HDL-cholesterol levels. Probucol is known to be a potent hypolipidemic drug to regress xanthoma fo...

Journal: :Journal of the American Society of Nephrology : JASN 2006
Shuji Kondo Maki Shimizu Maki Urushihara Koichiro Tsuchiya Masanori Yoshizumi Toshiaki Tamaki Akira Nishiyama Hiroshi Kawachi Fujio Shimizu Mark T Quinn David J Lambeth Shoji Kagami

Angiotensin II (Ang II) and reactive oxidative species (ROS) that are produced by NADPH oxidase have been implicated in the progression of glomerulonephritis (GN). This study examined the effect of simultaneously interrupting Ang II and ROS with an Ang II receptor blocker (ARB), candesartan, and a free radical scavenger, probucol, in a model of progressive mesangioproliferative GN induced by th...

2008
M. Makoto Ogawa Shiro Ueda Naohiko Anzai Masao Ohto

Makoto Ogawa, MD, First Department of Internal Medicine, Chiba University School of Medicine,1-8-1 Inohana, Chuouku (#260), Chiba (Japan) Dear Sir, Probucol is now widely used as potent antihyperlipidemic drug [1]. Experimental studies also showed that probucol reduced proteinuria and suppressed the development of various renal injuries [2-5]. So far, however, there have been few reports showin...

Journal: :Journal of the American College of Cardiology 2002
Ying Tung Sia Thomas G Parker Peter Liu James N Tsoporis Albert Adam Jean L Rouleau

OBJECTIVES The goal of this study was to evaluate whether reducing the potentially deleterious effects of oxidative stress with the potent anti-oxidant probucol improves prognosis after myocardial infarction (MI) in rats. BACKGROUND Oxidative stress has been documented in patients early and late after MI, particularly when it is associated with congestive heart failure. METHODS Rats survivi...

Journal: :The Journal of clinical investigation 1997
S H Zhang R L Reddick E Avdievich L K Surles R G Jones J B Reynolds S H Quarfordt N Maeda

Dietary administration of probucol (0.5%, wt/wt) efficiently reduced total plasma cholesterol levels in apolipoprotein E-deficient mice (apoE-/-) by 40%, with decreases in high density lipoprotein (HDL) and apoAI by 70 and 50%, respectively. Paradoxically, however, aortic atherosclerotic plaques in the probucol-treated apoE-/- mice formed more rapidly than in the untreated apoE-/- mice, and the...

2016
Yingqing Chen Indira Pandiri Yeonsoo Joe Hyo Jeong Kim Seul-Ki Kim Jeongmin Park Jinhyun Ryu Gyeong Jae Cho Jeong Woo Park Stefan W. Ryter Hun Taeg Chung

The selective type-3 phosphodiesterase inhibitor cilostazol and the antihyperlipidemic agent probucol have antioxidative, anti-inflammatory, and antiatherogenic properties. Moreover, cilostazol and probucol can regulate mitochondrial biogenesis. However, the combinatorial effect of cilostazol and probucol on mitochondrial biogenesis remains unknown. Endoplasmic reticulum (ER) stress is a well-k...

Journal: :Japanese journal of medicine 1989
H Matsuhashi S Onodera Y Kawamura N Hasebe C Kohmura H Yamashita K Tobise

Probucol administration of 4 weeks produced torsades de pointes associated with exacerbated QT interval prolongation in a 36-year-old woman with Romano-Ward syndrome. With discontinuance of probucol, the QT interval corrected for rate shortened from 620 msec to 500 msec and ventricular ectopic beats disappeared completely. Although probucol is known to prolong the QT interval, associated ventri...

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