Purpose: To determine the success of combined trabeculotomy and trabeculectomy with application Mitomycin C in primary congenital glaucoma. Study Design: Interventional case series. Place Duration Study: Mughal eye hospital Lahore from January 2018 to December 2019. Methods: Twenty-four patients glaucoma were included. Secondary corneal haze excluded. Corneal diameter above 11.5, 12.5 13 mm (wh...

PURPOSE To clinically and genetically characterize a distinct phenotype of congenital megalocornea (horizontal corneal diameter ≥13 mm) with secondary glaucoma from spherophakia and/or ectopia lentis during childhood in affected Saudi families. METHODS Clinical exam, homozygosity scan, and candidate gene analysis. RESULTS From 2005 to 2010, eight affected individuals from three consanguineo...

Noteworthy heterogeneity exists in the rare diseases associated with childhood glaucoma. Primary congenital glaucoma is mostly sporadic; however, 10% to 40% of cases are familial. CYP1B1 gene mutations seem to account for 87% of familial cases and 27% of sporadic cases. Childhood glaucoma is classified in primary and secondary congenital glaucoma, further divided as glaucoma arising in dysgenes...

Background: Glaucoma is a progressive optic neuropathy and is one of the leading causes of blindness worldwide. Different factors have been contributed in the pathogenesis of glaucoma including H. pylori infection. Objective: To determine the levels of anti-H. pylori IgG antibody in the aqueous humor of patients with pseudoexfoliation and primary open angle glaucoma, in comparison with age and ...

PURPOSE Two consanguineous Pakistani families with autosomal recessive primary congenital glaucoma were recruited to identify the disease locus. METHODS Ophthalmic examinations including slit lamp biomicroscopy and applanation tonometry were employed to classify the phenotype. Blood samples were collected and genomic DNA was extracted. A genome wide scan was performed on both families with 38...

PURPOSE To identify the disease-causing mutations in three consanguineous Pakistani families with multiple members affected by primary congenital glaucoma. METHODS Blood samples were collected, and DNA was extracted. Linkage analysis for reported primary congenital glaucoma loci was performed using closely spaced polymorphic microsatellite markers on genomic DNA from affected and unaffected f...

PURPOSE To compare findings of normal angles with those from primary congenital glaucoma in order to clarify the pathogenic mechanisms of the disease and to explain the success of surgical treatment in some of these patients. METHODS Adult normal eyes from cadavers and fragments of surgical trabeculectomies from patients with primary congenital glaucoma previously treated with goniotomy were ...

This paper aimed to assess the outcome of primary trabeculectomy for congenital glaucoma and to compare it with a combined trabeculotomy-trabeculectomy procedure. The combined procedure was assessed using a prospective trial for children with primary glaucoma under the age of 1 year (n = 16). The primary trabeculectomy was assessed retrospectively using similar patients treated at the same hosp...

The aim of this study was to compare the visual acuity and intraocular pressure (IOP) in children who underwent either trabeculotomy or trabeculectomy as an initial surgical procedure for primary congenital glaucoma.This retrospective study involved 38 eyes (21 patients) with primary congenital glaucoma treated by trabeculotomy and 45 eyes (26 patients) that underwent trabeculectomy. The inclus...

PURPOSE The human Cytochrome P450 gene CYP1B1 has been implicated in primary congenital glaucoma worldwide. The aim of this study was to understand the role of CYP1B1 mutations in causing primary congenital glaucoma in Indian populations. METHODS The study included 64 new and unrelated cases of primary congenital glaucoma from different ethnic groups of India. Direct sequencing screened the c...