نتایج جستجو برای: primary and metastatic melanoma

تعداد نتایج: 16947239  

2018
Fang Qi Zhiqi Yin Guangping Wang Sanwu Zeng

Tumor suppressor gene O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation has been reported in melanoma. However, the clinical and prognostic significance of MGMT promoter methylation in patients with melanoma remained to be determined. A systematic search was performed to identify eligible papers published. The overall odds ratios (ORs) or hazard ratios and their 95% confidence ...

Journal: :Investigative ophthalmology & visual science 2006
ShriHari S Kadkol Amy Y Lin Vivian Barak Inna Kalickman Lu Leach Klara Valyi-Nagy Dibyen Majumdar Suman Setty Andrew J Maniotis Robert Folberg Jacob Pe'er

PURPOSE This was a pilot study conducted to examine the expression of osteopontin in uveal melanoma and to determine whether serum osteopontin can be used in detecting metastatic uveal melanoma. METHODS Osteopontin mRNA was measured in three uveal melanoma cell lines of various invasive potential by real-time PCR. Tissue sections of primary and metastatic uveal melanomas were stained for oste...

2012
Eun Young Lee Jin-Oh Choi Ha Na Park Eun-Jung Park Gil Sun Lee Jun Young Park Jung-Sun Kim Eun Seok Jeon

Malignant melanoma has a very high propensity to metastasize to the heart. However, melanoma may sometimes present as a metastatic lesion in the absence of a primary lesion, which are called melanomas of unknown primary origin. We report a case in which a patient presented with a metastatic maligant melanoma in the right atrium with pericardial effusion and without a primary origin.

2014
Karli Rosner Darius R Mehregan Evangelia Kirou Judith Abrams Seongho Kim Michelle Campbell Jillian Frieder Kelsey Lawrence Brittany Haynes Malathy P V Shekhar

We have previously demonstrated that Rad6 and β -catenin enhance each other's expression through a positive feedback loop to promote breast cancer development/progression. While β -catenin has been implicated in melanoma pathogenesis, Rad6 function has not been investigated. Here, we examined the relationship between Rad6 and β -catenin in melanoma development and progression. Eighty-eight cuta...

2018
Jessica Yang Daniel K. Manson Brian P. Marr Richard D. Carvajal

Uveal melanoma, a rare subset of melanoma, is the most common primary intraocular malignancy in adults. Despite effective primary therapy, nearly 50% of patients will develop metastatic disease. Outcomes for those with metastatic disease remain dismal due to a lack of effective therapies. The unique biology and immunology of uveal melanoma necessitates the development of dedicated management an...

Journal: :Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 1998
T S Wang L Lowe J W Smith I R Francis V K Sondak L Dworzanian S Finkelstein C L Slingluff T M Johnson

BACKGROUND Complete spontaneous regression of melanoma metastatic to the lungs is a rare event. OBJECTIVE To report a case of biopsy-proven melanoma metastatic to the lung with complete spontaneous regression. METHODS Multidisciplinary case report. RESULTS A 35-year-old white female was diagnosed with metastatic melanoma to the lung. A pleural biopsy confirmed the diagnosis. Partial spont...

2013
Héctor Peinado Maša Alečković Simon Lavotshkin Irina Matei Bruno Costa-Silva Gema Moreno-Bueno Marta Hergueta-Redondo Caitlin Williams Guillermo García Ayuko Nitadori-Hoshino Caitlin Hoffman Karen Badal Benjamin A. Garcia Margaret K. Callahan Jianda Yuan Vilma R. Martins Johan Skog Rosandra N. Kaplan Mary S. Brady Jedd D. Wolchok Paul B. Chapman Yibin Kang Jacqueline Bromberg David Lyden

Tumor-derived exosomes are emerging mediators of tumorigenesis with tissue-specific addresses and messages. We explored the function of melanoma-derived exosomes in the formation of primary tumor and metastases in mouse and human subjects. Exosomes from highly metastatic melanoma increased the metastatic behavior of primary tumors by permanently “educating” bone marrow (BM) progenitors via the ...

Journal: :iranian biomedical journal 0
پریسا موسوی شفاعی parisa mousavi-shafaei عبدعلی ضیایی abed-ali ziaee uwe zangemeister-wittke

background: malignant melanoma is a highly metastatic cutaneous cancer and typically refractory to chemotherapy. deregulated apoptosis has been identified as a major cause of cancer drug resistance, and upregulated expression of the inhibitor of apoptosis protein melanom, an inhibitor of apoptosis (ml-iap) is frequent in melanoma. methods: based on the conclusion that ml-iap expression contribu...

Journal: :The British journal of ophthalmology 1979
L W Hirst J Reich J E Galbraith

We describe a case of cutaneous malignant melanoma metastatic to the iris as the first presenting sign of metastases 10 years after excision of the primary tumour. The histology of the excised iris metastases and the primary skin melanoma are compared. Progressive intracranial metastatic growth did not correlate with the observed regression of the residual intraocular melanoma cells during cycl...

2017
Aniruddha Chatterjee Peter A Stockwell Antonio Ahn Euan J Rodger Anna L Leichter Michael R Eccles

Epigenetic alterations are increasingly implicated in metastasis, whereas very few genetic mutations have been identified as authentic drivers of cancer metastasis. Yet, to date, few studies have identified metastasis-related epigenetic drivers, in part because a framework for identifying driver epigenetic changes in metastasis has not been established. Using reduced representation bisulfite se...

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