This paper presents a numerical simulation of the flow characteristics through a patient-specific model of an aortic coarctation. The purpose of the study was to predict the pressure gradient at rest and at exercise conditions. The commercial package ADINA was used to numerically solve the governing equations using finite-elements methods. The model was based on the patient's MR angiography dat...

This study examined production of word-final English /p/ and /b/ by subjects whose native language does not possess voiced stops in word-final position. Native Chinese adults resembled native English adults, native English children, and native Chinese children in producing /p/ with greater peak oral air pressure than /b/. However, unlike subjects in the other groups, the Chinese adults' /b/ was...

The influence of an aortic aneurysm on blood flow waveforms is well established, but how to exploit this link for diagnostic purposes still remains challenging. This work uses a combination of experimental and computational modelling to study how aneurysms of various size affect the waveforms. Experimental studies are carried out on fusiform-type aneurysm models, and a comparison of results wit...

The American Thoracic Society (ATS) recently adopted a new set of 26 standard flow-time waveforms for use in testing both diagnostic and monitoring devices. Some of these waveforms have a higher frequency content than present in the ATS-24 standard volume-time waveforms, which, when produced by a mechanical pump, may result in a pump flow output that is less than the desired flow due to gas com...

BACKGROUND The information contained in arterial pressure waveforms is probably underused by most clinicians who manage critically ill patients. It is not generally known that an aortic pressure wave can be synthesized by applying a generalized transfer function to the radial arterial pressure wave. We validated a commercially available system, SphygmoCo (PWV Medical, Sydney). METHODS Ascendi...

INTRODUCTION Systolic pressure variation has previously been used to detect the presence of hypovolemia in mechanically ventilated patients but remains difficult to measure. METHODS We describe the application of a commercially available physiological data acquisition system, PowerLab (ADI Instruments Castle Hill, NSW, Australia), to acquire and graphically display simultaneous recordings of ...

In this paper, a mathematical model of the respiratory mechanics is used to reproduce experimental signal waveforms acquired from three newborn lambs. As the main challenge is to determine specific lamb parameters, a sensitivity analysis has been realized to find the most influent parameters, which are identified using an evolutionary algorithm. Results show a close match between experimental a...