PURPOSE Stress during pregnancy is a risk factor for the development of anxiety-related disorders in offspring later in life. The effects of treadmill exercise on anxiety-like behaviors and hippocampal cell proliferation were investigated using rats exposed to prenatal stress. METHODS Exposure of pregnant rats to a hunting dog in an enclosed room was used to induce stress. Anxiety-like behavi...

the purpose of this study was to evaluate the effect of two regimes during rats' gestation and lactation on learning, memory and motor function of their offspring. for this purpose, female rats (albino-wistar) were obtained from pasteur institute, iran. after mating, 12 pregnant rats were divided into three groups and they had their special regimes during their last week of pregnancy as we...

OBJECTIVE Lead is a common environmental contaminant. Lead accumulation in the body is especially dangerous for pregnant women and newborns. Selenium is a trace element which may rectify the damaging effects of lead. Here we tested potential protective effects of selenium against gestational lead exposure. MATERIALS AND METHODS Pregnant SD rats were exposed to 200 mg/L of lead acetate (given ...

  Objective(s): Epilepsy is a neurodevelopmental disorder which is strongly influenced by genetic and environmental factors. Gestational stress has been shown to be an important factor for affecting seizure susceptibility. The present study was conducted to address whether gestational stress may affect pentylentetrazol (PTZ)-induced epileptic behavior in rat offspring in a sex- and a...

OBJECTIVE Epidemiological studies suggest that intrauterine undernutrition plays an important role in the development of arterial hypertension in adulthood. In an attempt to define the mechanisms whereby blood pressure may be raised, we have hypothesized that arteries from offspring of nutritionally restricted dams exhibit abnormalities in the endothelial function and in nitric oxide synthesis....

We investigated the actions of isoflavones (daidzin + daidzein 22.7%, daidzein 16.9%, genistin + genistein 16.3%, genistein 13.1%) in pregnant rats, assessing possible repercussions regarding the development of female conceptus. Doses of isoflavones, 10 mg/kg or 100 mg/kg, were administered to pregnant rats by oral gavage, from the sixth day of pregnancy until its completion. The pregnant rats ...

this study was conducted to evaluate the effects of maternal diabetes on fetal spinal structure, especiallyin brachial enlargement. sixteen adult female rats were divided into two groups. diabetes was induced in one group by alloxan agent. both groups became pregnant by natural matting. on days 7, 14, 21 and 28 after birth, the brachial enlargement of the spinal cord was collected from offsprin...

introduction: stress has many effects on the development of systems and organs in the fetal period, and these effects appear after birth. since hemopoietic system is susceptible to stress, effects of restraint stress were studied in offspring of pregnant rats. methods: pregnant rats were divided into one control and three stress groups. the control group did not receive any stress during the ge...

OBJECTIVE Obesity in pregnancy significantly increases the risk of the offspring developing obesity after birth. The aims of this study were to test the hypothesis that maternal obesity increases oxidative stress during fetal development, and to determine whether administration of an antioxidant supplement to pregnant Western diet-fed rats would prevent the development of adiposity in the offsp...