Preeclampsia is a systemic disease of pregnancy characterized by maternal hypertension, proteinuria, and edema. These clinical pathological findings may be attributed to abnormalities in vascular endothelial activation secondary to increased oxidative stress. To test the hypothesis that increased circulating lipid peroxides in preeclamptic women activate vascular endothelial cells, we determine...

Rats harboring the human angiotensinogen and human renin genes develop preeclamptic features in pregnancy. The preeclamptic rats exhibit a deeper trophoblast invasion associated with a reduced resistance index by uterine Doppler. Doxycycline inhibits matrix metalloproteinase activity. We tested the hypothesis that matrix metalloproteinase inhibition reduces trophoblast invasion with subsequent ...

Plasma membrane Ca-ATPase activity diminishes by about 50% in red blood cells during preeclampsia. We investigated whether the number of Ca-ATPase molecules is modified in red cell membranes from preeclamptic pregnant women by measuring the specific phosphorylated intermediate of this enzyme. Also, we isolated the Ca-ATPase protein from both normotensive and preeclamptic pregnant women and esti...

The aim of this study is to assess vitamin D levels in eclampsia, preeclampsia and healthy pregnant women and the role of vitamin D deficiency in the etiology of preeclampsia (PE). Forty healthy pregnant women, 83 preeclamptic and 32 eclamptic pregnant women were included. Maternal and infant medical records were reviewed. Blood samples were obtained from all groups. Demographics and serum vita...

OBJECTIVE Systemic endothelial dysfunction is a central feature in the pathophysiology of preeclampsia. Its cell biologic and molecular basis is poorly understood. One leading hypothesis argues that endothelial dysfunction is caused by (at present largely unknown) circulating factors released from the ischemic placenta. This study investigated the effects of plasma factors of severe, early-onse...

background: preeclampsia is a condition observed during pregnancy and threatens the life of both mother and fetus. there are studies which suggest that preeclampsia play a major role in the left ventricular mass. the aim of this study is to compare the electrocardiographic changes in normal pregnant and preeclamptic women. methods: the studied groups consisted of 48 mild preeclamptic, 33 severe...

INTRODUCTION The etiology of preeclampsia is not fully established. A few studies have shown a relationship between natural coagulation inhibitors and preeclampsia. OBJECTIVES The purpose of this study was to investigate the status of natural coagulation inhibitors and active protein C resistance (APC-R) in preeclampsia. PATIENTS AND METHODS We studied 70 women with preeclampsia recruited c...

OBJECTIVE Formerly preeclamptic women with low plasma volume are at increased risk of recurrent gestational hypertensive disease. We hypothesized that a 4-week cycling training in formerly preeclamptic women improves (venous) hemodynamic function. METHODS In 9 formerly preeclamptic women, we examined physical fitness and hemodynamic function, before and after the training. We assessed blood p...

Preeclampsia is a potentially life threatening disorder of pregnancy which presents with raised blood pressure and proteinuria after twentieth week of gestation. It is one of the leading and mystical causes of maternal and fetal mortality worldwide. Abnormal placentation is suggested to be possibly the key feature of this disorder. Preeclampsia has been attributed to the presence of a circulati...