TOPIC: Critical Care TYPE: Original Investigations PURPOSE: Diabetes mellitus is a known risk factor in the development of sepsis. Studies have shown worse outcomes critical patients with poor glycemic control, but recent meta-analysis showed improved sepsis diabetes. Considering inconclusive findings, we aim to further assess burden and admissions non-diabetics prediabetes. METHODS: The Nation...

OBJECTIVE Prediabetes is a dysglycemic state and is associated with subtle myocardial injury and dysfunction. We evaluated atrial conduction times (ACTs) and atrial electromechanical delays (EMDs) in prediabetic patients with coronary artery disease (CAD). METHODS In the present study, we recruited 128 consecutive patient candidates (40 euglycemic, 48 prediabetic, and 40 diabetic patients) fo...

BACKGROUND Excess serum uric acid (UA) accumulation can lead to various diseases. Increasing evidences reveal that UA may have a key role in the pathogenesis of metabolic syndrome. Little is known about the associations of UA levels with cardiometabolic risk factors in prediabetic individuals. This study was designed to evaluate the association between UA and cardiometabolic risk factors in pre...

Type 1 diabetes mellitus (IDDM) results from a chronic process of autoimmune destruction of beta cells of the Langerhans islets. The presence of autoantibodies (ICA, GADA, anti-IA2, IAA) in serum precedes the clinical onset of the disease. Genetic predisposition for IDDM is connected with HLA, CTLA-4 and insulin gene region. The aim of the study was the genetic and immunological analysis of a t...

BACKGROUND Subjects who convert to type 2 diabetes mellitus have increased cardiovascular risk factors relative to nonconverters. However, it is not known whether these atherogenic changes in the prediabetic state are predominantly due to insulin resistance, decreased insulin secretion, or both. METHODS AND RESULTS We examined this issue in the 7-year follow-up of the San Antonio Heart Study,...

Gap junctional intercellular communication between β-cells is crucial for proper insulin biosynthesis and secretion. The aim of this work was to investigate the expression of connexin (Cx)36 at the protein level as well as the function and structure of gap junctions (GJ) made by this protein in the endocrine pancreas of prediabetic mice. C57BL/6 mice were fed a high-fat (HF) or regular chow die...

BACKGROUND Dyslipidemia occurring in diabetic patients, play a critical role in acceleration of macrovascular atherosclerosis and contribute to the excess risk of CVD. Keeping in view the prevalence and increased risk of cardiovascular disease in diabetes, it is becoming necessary to diagnose prediabetic individuals and assess their lipid profile and prevent them from developing overt diabetes ...

BACKGROUND Recent evidence has suggested an association between subclinical hypothyroidism (SCH) and microalbuminuria in patients with type 2 diabetes. However, whether SCH is related to microalbuminuria among subjects with prediabetes has not been studied. Thus, we evaluated the association between SCH and microalbuminuria in a cohort of prediabetic Egyptian adults. METHODS A total of 147 pr...

Background: Diabetes mellitus, a group of metabolic disorder with multiple etiologies is characterized by chronic hyperglycaemia, induced deficiency insulin production and action. Prediabetes type hyperglycemia in which glycemic indices are higher than normal but lower the diabetes threshold. Objective: This study aims to assess impact bone markers (serum calcium, phosphorus alkaline phosphatas...