This study evaluated preclinical and clinical safety of marshmallow (Althaea officinalis L.) extract as a naturopathic medicine in common carp deliberately infected with Aeromonas hydrophila. The fish were fed 0 (control), 2.50, 5.00 and 10.00 g of marshmallow extract for 60 days in a preclinical experiment and then, challenged with A. hydrophila for a 10-day experime...

Ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), showed very promisingneuroprotection action, but it suffers from high first pass metabolism and limited abilityto cross blood brain barrier. Severe gastric toxicity following oral administration furtherlimits its utility. Hence, the aim of this study was to investigate whether ibuprofen loadedmucoadhesive microemulsion (MMEI) could enha...

Ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), showed very promisingneuroprotection action, but it suffers from high first pass metabolism and limited abilityto cross blood brain barrier. Severe gastric toxicity following oral administration furtherlimits its utility. Hence, the aim of this study was to investigate whether ibuprofen loadedmucoadhesive microemulsion (MMEI) could enha...

stroke is a significant public health burden which absolutely requires more effective therapies. the approved treatment options for stroke including tissue plasminogen activators, antiplatelet agents and anticoagulants mainly bear antithrombotic effects. meanwhile, evolving investigational approaches such as collateral therapeutics and neuroprotective agents has thus far been attempted with equ...

On April 6, 2009, an earthquake of 6.3 magnitude struck central Italy with its epicentre near L'Aquila, at 42.3502° N, 13.3762°E. The earthquake damaged 3,000 to 11,000 buildings in the medieval city of L'Aquila. Several buildings totally collapsed, 308 people were killed. The post emergency phase till now is just at its beginning step. Conventional surveying techniques using high precision tot...

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20 CHAPTER