نتایج جستجو برای: ppara
تعداد نتایج: 391 فیلتر نتایج به سال:
Compounds that target the peroxisome proliferator-activated receptors PPARa and PPARg are used to correct dyslipidemia and to restore glycemic balance, respectively. Because the majority of diabetic patients suffer from atherogenic lipid abnormalities, in addition to insulin resistance, ligands are required that can activate both PPARa and PPARg. In this study, we used chimeric PPARa/g reporter...
Fatty acid b-oxidation occurs in both mitochondria and peroxisomes. Long chain fatty acids are also metabolized by the cytochrome P450 CYP4A v-oxidation enzymes to toxic dicarboxylic acids (DCAs) that serve as substrates for peroxisomal b-oxidation. Synthetic peroxisome proliferators interact with peroxisome proliferator activated receptor a (PPARa) to transcriptionally activate genes that part...
Background—Monocytic tissue factor (TF) expression may contribute to thrombogenicity associated with plaque rupture and may propagate thrombus formation at the site of vascular lesions. Induction of monocytic TF expression by endotoxin is mediated by the activation of transcription factors such as AP-1 and NF-kB. Both these signaling pathways are modulated by peroxisome proliferator–activated r...
The peroxisome proliferator activated receptor a (PPAR) is a member of the steroid/hormone receptor superfamily that mediates the peroxisome proliferator-dependent transcriptional activation of genes encoding several peroxisomal and microsomal enzymes as well as peroxisome proliferation. Human liver is refractory to the pathological effects of peroxisome proliferators that are seen in mice. Wit...
Peroxisome proliferator–activated receptors (PPARs) form a family of nuclear hormone receptors involved in energy hemostasis and lipid metabolism (1,2) and include three isotypes encoded by different genes: PPARa (chromosome22q12–13.1), PPARb/d (chromosome 6p21.2–21.1), and PPARg (chromosome 3p25). PPARa was the first discovered and causes cellular peroxisome proliferation in rodent livers (3),...
WINNING ABSTRACT: Persistent inflammation is the main pathological process that underlies COPD. Understanding this inflammatory response is a key focus of COPD research with the aim of discovering new therapeutic targets. The nuclear hormone receptor, PPAR is now a recognised modulator of inflammation in various chronic inflammatory conditions, but its role in the persistent airways inflammatio...
OBJECTIVE Neuroinflammation contributes to the pathogenesis of sporadic Alzheimer's disease (AD). Variations in genes relevant to inflammation may be candidate genes for AD risk. Whole-genome association studies have identified relevant new and known genes. Their combined effects do not explain 100% of the risk, genetic interactions may contribute. We investigated whether genes involved in infl...
Phenprocoumon is an anticoagulant used for thromboembolic disorder prophylaxis metabolized mainly by CYP3A4. However, polymorphisms in this gene did not explain the observed variability. PPARA (peroxisome proliferator-activated receptor-α) is a nuclear receptor that, among others, influences CYP3A4 gene expression. The aim of this study was to determine whether PPARA gene polymorphisms and the ...
Phytol, a branched-chain fatty alcohol, is the naturally occurring precursor of phytanic and pristanic acid, branched-chain fatty acids that are both ligands for the nuclear hormone receptor peroxisome proliferator-activated receptor a (PPARa). To investigate the metabolism of phytol and the role of PPARa in its regulation, wild-type and PPARa knockout (PPARa) mice were fed a phytolenriched die...
Adiponectin is a circulating adipose-derived cytokine that may act as an antioxidative and anti-inflammatory protein. Although adiponectin has been reported to exert cytoprotective effects in acute cardiac diseases, its effects on chronic heart failure are less clear. Therefore, we aimed to investigate whether adiponectin would have a beneficial effect in iron-induced chronic heart failure and ...
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