Remifentanil is a very potent ultrashort acting opioid, that is mainly used as a part of balanced anaesthesia regimens for management of intraoperative pain. Effective plasma levels of this drug can only be maintained using continuous infusions, as tissue esterases inactivate remifentanil within minutes following its application. The advantages of this specific pharmacokinetic behaviour are tha...

Pain is one of the most distressing post-operative consequences of surgeries. Opioids have been the mainstay in providing pain relief. Morphine is the considered to be the “gold standard” amongst opioids as an analgesic. Nalbuphine, a synthetic opioid agonist/antagonist has analgesic potency almost equivalent to that of morphine on a milligram basis and fewer complications like respiratory depr...

Background And Aims: The transversusabdominis plane block is a new rapidly expanding regional anesthesia technique that provide analgesia of Anterior abdominal wall surgeries. TransversusAbdomimis Plane block significantly reduces pain associated with lower abdominal surgeries. It may be used as primary anesthesia or Post operative analgesia.The present study aims to “Comparative study of 0.2% ...

Effective pain relief is an essential component of a patient's peri-operative care package. Good analgesia has been shown to reduce the incidence of cardiovascular, respiratory and thrombo-embolic complications following surgery. Satisfactory analgesia facilitates early patient ambulation following surgery, which may reduce in-patient stay. Patient-controlled analgesia (PCA) systems are a well ...

BACKGROUND There is an ongoing debate whether opioids when used for intra-operative analgesia may enhance post-operative pain. We studied the effect of two different intra-operative dosings of sufentanil on post-operative morphine consumption, pain and hyperalgesia after cardiac anaesthesia. METHODS Forty-two male patients (age: 48-74 years) undergoing first-time coronary artery bypass graft ...

Background: Acute and chronic pain is prevalent in patients with opioid dependence. Lack of knowledge concerning the complex relationship between pain, opioid use, and withdrawal syndrome can account for the barriers encountered for pain management. This study was designed to evaluate the efficacy of sublingual (SL) buprenorphine for post-operative analgesia, compared with intravenous (IV) morp...

The optimal form of post-operative analgesia in hip and knee arthroplasty is still debated. Traditionally, patient-controlled analgesia and epidural anaesthesia were used. Potential side-effects such as nausea, confusion, urinary retention, hypotension and immobility have resulted in the emergence of newer techniques that limit opioid use. Peripheral nerve blockade provides excellent analgesia ...