BACKGROUND Graded activity and graded exposure are increasingly being used in the management of persistent low back pain; however, their effectiveness remains poorly understood. PURPOSE The aim of this study was to systematically review randomized controlled trials that evaluated the effectiveness of graded activity or graded exposure for persistent (>6 weeks in duration or recurrent) low bac...

This paper investigates the physical, chemical, and microstructural properties of two types natural sand; alluvial sands dune sand from El-Oued region in northeastern Algerian Sahara. Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), Fluorescence (XRF), Scanning electron microscopy (SEM/EDS), granulometry analysis have been performed. The FTIR XRD prove that consist high ...

Let $G$ be a monoid with identity $e$. In this paper, first we introduce the notions of $G$-graded hyperrings, graded hyperideals and graded hyperfields in the sense of Krasner hyperring $R$. Also, we define the notion of a greded $R$-hypermodules and some examples are presented. Then we investigate graded maximal, graded prime and graded primary hyperideals of a graded hyperring $R$. Finally, ...

Molecular mechanisms underlying the coordination of isotype switching with plasma cell differentiation are poorly understood. We show that interferon regulatory factor-4 (IRF-4) regulates both processes by controlling the expression of the Aicda and Prdm1 genes, which encode AID and Blimp-1, respectively. Genome-wide analysis demonstrated that Irf4(-/-) B cells failed to induce the entire Blimp...

Hepatocellular carcinoma (HCC) that is graded histologically as poorly differentiated has a high recurrence, metastasis and poor prognosis. We sought to determine the regulatory mechanisms of HCC tumorigenesis and to identify molecules closely related to poorly differentiated HCC. High-throughput sequencing was used to construct microRNA (miRNA) and mRNA expression profiles for poorly different...

Let $G$ be a group with identity $e$ and $R$ be a commutative $G$-graded ring with nonzero unity $1$. In this article, we introduce the concept of graded $r$-ideals. A proper graded ideal $P$ of a graded ring $R$ is said to be graded $r$-ideal if whenever $a, bin h(R)$ such that $abin P$ and $Ann(a)={0}$, then $bin P$. We study and investigate the behavior of graded $r$-ideals to introduce ...

Effective use of natural materials and industrial by products has a direct impact on economy, sustainable environment, waste management. Poorly graded desert sand (SP) is widely observed in dunes seas. Studies were performed to get beneficial cement kiln dust (CKD) soil improvement. But there lack information concerning using CKD as an improving material for poorly with the aid salt water. Salt...

UNLABELLED Patients with advanced cancer who have pain that responds poorly to opioid therapy pose a clinical challenge. Nabiximols (Nabiximols is the U.S. Adopted Name [USAN] for Sativex [GW Pharma Ltd, Wiltshire, U.K.], which does not yet have an INN), a novel cannabinoid formulation, is undergoing investigation as add-on therapy for this population. In a randomized, double-blind, placebo-con...