A Ni(ClO4)2-catalyzed enantioselective [2 + 2] cycloaddition ofN-allenamides with cyclicN-sulfonylketimines was developed, which regioselectively occurred at the proximal C]C bonds of the N-allenamides. Broad substrate scope of N-allenamides and cyclic N-sulfonylketimines was observed. A range of fused polysubstituted azetidines bearing quaternary stereocenters were afforded in good yields and ...

An undescribed phyllocoumarin-3-O-α-L-rhamnopyranoside 8 together with catechin 1, catechin-3-O-α-L-rhamnopyranoside 2, catechin-[7,8-bc]-4β-(3,4-dihydroxyphenyl)-dihydro-2(3H)-pyranon 3, 5-O-trans-p-coumaroylquinic acid 4, trans-p-coumaric 5, catechin-[5,6-e]-4β-(3,4-dihydroxyphenyl)-dihydro-2(3H)-pyranon 6, catechin-[5,6-e]-4α-(3,4-dihydroxyphenyl)-dihydro-2(3H)- pyranon 7, phyllocoumarin 9 a...

Reaction of methyl-2-(2-formylphenyl)acetate with primary amines in a reductive amination/cyclisation process resulted N-substituted 1,4-dihydro-3(2H)-isoquinolinones. With H2NCH2R sodium borohyride is suitable reductant (11 examples), but H2NCHR1R2 required transfer hydrogenation using ammonium formate catalysed by palladium on carbon (9 examples). 4-Substituted-1,4-dihydro-3(2H)-isoquinolinon...

Chemoselective phosphine-catalyzed cascade [2 + 2 + 2] and [2 + 2 + 1] annulations between two molecules of 2-arylmethylidene cyanoacetates or malononitriles and one molecule of α,β-unsaturated ketones have been developed. Under the nucleophilic catalysis of PPh(3) or PBu(3) (10 mol%), a highly diastereoselective synthesis of polysubstituted cyclohexanes or cyclopentenes has been successfully a...

A Ni(ClO4)2-catalyzed enantioselective [2 + 2] cycloaddition of N-allenamides with cyclic N-sulfonylketimines was developed, which regioselectively occurred at the proximal CC bonds of the N-allenamides. Broad substrate scope of N-allenamides and cyclic N-sulfonylketimines was observed. A range of fused polysubstituted azetidines bearing quaternary stereocenters were afforded in good yields and...

Palladium-catalyzed cross-coupling of furfural tosylhydrazones with 2-iodoanilines or 2-iodothiophenols produces polysubstituted indoles or benzothiophenes, respectively. The reaction proceeds through 2-furylmethylene palladium iodide intermediates, which undergo furan ring opening followed by ring closure to form indoles or benzothiophenes. This reaction will expand the synthetic applications ...

The genus Boswellia is one of the 17 genera belonging to Burseraceae family. In this study resin of Boswellia carteri birdwoodcollected or purchased from Tehram herbal Market as a food and non-food for chemical analysis. The essential oils of the resins of Boswellia carteri birdwoodobtained by different methods of distillation (water distillation, steam distillation and hydro-steam distillation...

An efficient relay catalytic process involving Au(i)/Brønsted acid to access various polysubstituted cyclopentannulated indoles from easily accessible 1-(2-aminophenyl)prop-2-ynols and readily available 1,3-dicarbonyls has been developed. In an unprecedented event, the intermediate 2-indolylmethyl cations undergo the cation-Ene reaction with various 1,3-dicarbonyls followed by an intramolecular...

Abstract Inverse electron-demand Diels–Alder additions (iEDDA) between 1,2,4,5-tetrazines and suitable unsaturated dienophiles such as olefins, alkynes, or enol ethers provide facile access to pyridazines. Herein the use of cyclic ether derivatives for preparing pyridazines bearing 2-hydroxyethyl, 3-hyproxypropyl, 3-oxopropyl substituents at 4-position is disclosed second order rate constants r...