Modulating the extracellular matrix microenvironment is critical for achieving desired macrophage phenotype in immune investigations or tumor therapy. Combining de novo protein design and biosynthesis techniques, herein, we designed a biomimetic polypeptide self-assembled nano-immunomodulator to trigger activation of specific phenotype. It was intended be made up (​GGS​GGP​GGG​PAS​AAA​NSA​SRA​T...

Pancreatic Polypeptide (PP) is a 36 amino acid peptide produced and secreted by PP cells (originally termed F cells) of the pancreas which are primarily located in the Islets of Langerhans. It is part of a family of peptides that also includes Peptide YY (PYY) and Neuropeptide Y (NPY). PP is rapidly released after a meal but remains elevated for 4-6 hours in humans with the Vagus nerve being th...

HIGHLIGHTS The FvEPSPS encodes a polypeptide of 520 amino acids. was constitutively expressed in stems, leaves and roots, with lower expression roots. level could increase significantly glyphosate treatment. Transgenic Arabidopsis Thaliana gene exhibited 10 mM to resistance.

The activation of stimulator interferon genes (STING) in the cytosol by cyclic dinucleotides (CDNs) enhances antitumor immunity through induction proinflammatory cytokines, such as type-I interferons (IFN-I). However, high hydrophilicity and negative charge CDNs hinders their delivery into cells. Here, developing a library cationic polypeptide-modified dendrimers, it is shown that can be effici...

Pancreatic polypeptide is a 36-amino acid peptide which inhibits pancreatic exocrine function. We have previously determined from the nucleotide sequence of a cDNA that pancreatic polypeptide is derived from a 95-amino acid precursor, prepropancreatic polypeptide. Pulse-chase studies have suggested that the precursor is cleaved to produce three peptides: pancreatic polypeptide, an icosapeptide,...

Partial amino acid sequences have been determined for a 4.0-kDa photosystem I polypeptide from barley. A comparison with the sequence of the chloroplast genome of Nicotiana tabacum and Marchantia polymorpha identified the polypeptide as chloroplast-encoded. We designate the corresponding gene psaI and the polypeptide PSI-I. The barley chloroplast psaI gene was sequenced. The gene encodes a poly...

Our previous finding that the tumor suppressor p53 is covalently linked to 5.8S rRNA suggested functional association of p53 polypeptide with ribosomes. p53 polypeptide is expressed at low basal levels in the cytoplasm of normal growing cells in the G1 phase of the cell cycle. We report here that cytoplasmic wild-type p53 polypeptide from both rat embryo fibroblasts and MCF7 cells and the A135V...

We have previously found that a partially 2-deoxygenated (P2D)-amylose, produced by glucan phosphorylase (GP)-catalyzed enzymatic copolymerization, shows hydrophobic nature. Based on this finding, the present study demonstrates hydrophobization of strong hydrophilic polypeptide, i.e., poly(γ-glutamic acid) (PGA), grafting P2D-amylose chains via GP-catalyzed approach. After maltooligosaccharide ...

The structural polypeptides of two strains of measles virus grown in Vero cells were analysed in SDS-PAGE slab gels. Six major polypeptides were identified with mol. wt. of 79000, 72000, 60000, 43000, 40000 and 36000. The largest polypeptide was sensitive to trypsin digestion and was the dominant glycosylated polypeptide identified when the virus was grown in medium containing 3H-fucose or 3H-g...