Recently, polymeric nanoparticles (NPs) have attracted enormous attention as targeted drug delivery vehicles.[1-4] Especially, biodegradable and biocompatible polymeric NPs comprised of poly(lactide-co-glycolide)-b-polyethyleneglycol (PLGA-PEG) block copolymers exhibit optimal physicochemical characteristics such as the ability to incorporate various targeting agents, enhanced immune evasion, c...

the available minoxidil formulations for topical application suffer with major drawback having less contact time with the scalp which requires repeated application. hence, the present study was aimed to investigate the effect of microemulsions and microemulsion based hydrogel systems (mehs) for increased percutaneous penetration of minoxidil. minoxidil microemulsions were developed by following...

Polyethyleneglycol bound sulfonic acid (PEG-OSO₃H), a chlorosulphonic acid-modified polyethylene glycol was successfully used as an efficient and eco-friendly polymeric catalyst in the synthesis of 14-aryl/heteroaryl-14H-dibenzo[a,j]xanthenes obtained from the reaction of 2-naphthol and carbonyl compounds under solvent-free conditions with short reaction times and excellent yields. The biologic...

Previous studies highlighted the anaphylactoid nature of liposome reactions, pointing to activation of the complement (C) system as probably the underlying cause [13]. It was also established earlier that multilamellarity, large size, and the presence of very high amounts of cholesterol in the bilayer membrane are likely one of the main cause of C activation and anaphylactoid reactions. More re...

Fe(3)O(4) (magnetite) nanocrystals with an average size of 13 nm were prepared using a specially synthesized polymeric stabilizer (poly-4-vinylpyridine-co-acrylamidoethylamine-co-polyethyleneglycol-co-polyethyleneglycolic acid) that bears reactive groups for further functionalization. The polymer shell made the nanocrystals amphiphilic, i.e. they are soluble in pentanol, water and dichlorometha...

A new strategy has been developed to achieve durable, low surface tension fluorinated polymeric materials by copolymerizing a tetramethacryloxy-modified perfluoropolyether (PFPE) macromonomer and a fluorinated difunctional cross-linker, 1H,1H,6H,6H-perfluoro-1,6-hexyl diacrylate (PFHDA), into very highly cross-linked materials that possess a very high modulus as well as a very low surface energ...

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