Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder and the most common cause of female infertility. However, its etiology and underlying mechanisms remain unclear. Here we report that a transgenic obese mouse (Mito-Ob) developed by overexpressing prohibitin in adipocytes develops polycystic ovaries. Initially, the female Mito-Ob mice were equally fertile to their wild-type litte...

BACKGROUND Polycystic ovarian syndrome (PCOS) is a controversial endocrine pathology and, recently, it has been suggested that the condition is hereditary. The aim of this study was to prospectively determine in daughters of patients with PCOS, by ultrasonographic (US) and colour Doppler analyses, the incidence of polycystic ovaries and search any correlation with specific hormonal parameters. ...

OBJECTIVE Limited data suggest that menstrual cycle abnormalities are more pronounced in younger and more obese patients with polycystic ovary syndrome (PCOS). We aimed to evaluate the association between menstrual cycle pattern and age, obesity and PCOS phenotype in a large population of women with PCOS. DESIGN We studied 1,297 women with PCOS and divided them according to: a) age in ≤ 20, 2...

The writing of an article about this condition presents considerable difficulties. It is found in a numbet of separate disorders and is not therefore an entity in itself, though a common final mechanism may be typically involved. Moreover, a number of matters are involved about which knowledge is confused, fragmentary or uncertain. It is proposed to consider various aspects of the subject separ...

Differences in the secretion of estrogens by follicular polycystic ovaries of androgen-sterilized rats and by normal follicular ovaries of early proestrous rats were compared. Some rats were injected i.v. with LH 30 min before bleeding. This injection of LH did not influence the secretion of estrogens by normal ovaries, but greatly increased that by polycystic ovaries, suggesting that there was...

BACKGROUND Polycystic ovaries (PCO) are described on ultrasound scan as the “presence of 12 or more follicles in each ovary measuring 2–9 mm in diameter, and/or increased ovarian volume (>10 ml)”1. Polycystic ovarian syndrome (PCOS) or disease (PCOD) is diagnosed when polycystic ovaries are associated with chronic anovulation and clinical and/or biochemical androgen excess (typically featured a...

introduction: ninety four females who attended at the ultrasound department of royal hospital for women underwent a transabdominal ultrasound to detect polycystic ovaries (pco). material and methods: thirty-seven individuals had scan normal ovaries and 38 had scan evidence of polycystic ovary (pco). all the subjects were sent a bulimia investigation test (edinburgh) (bite) questionnaire for abn...

We studied both morphology and steroidogenic activity of porcine ovaries after dexamethasone (DMX)-induced polycystic status. In the polycystic-changed ovaries, an increase in the number of DbetaH-IR and/or NPY-IR nerve terminals was found in the wall of follicles, cysts and blood vessels. After DXM injections, we observed changes in the mean contents of progesterone, androstendione, estradiol-...