A combination of drugs reduces the growth cysts related to autosomal dominant polycystic kidney disease.

OBJECTIVES To assess the prevalence of renal abnormalities in ragdoll cats. Ragdoll breeders often warn clients to watch for future renal problems, mainly due to chronic interstitial nephritis and polycystic kidney disease. Therefore, ragdoll screening by abdominal ultrasonography, measurement of serum creatinine and urea concentrations and genetic testing is often performed without documented ...

Clarke WR et al. Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes. Identification of patients with autosomal dominant polycystic kidney disease at highest risk for end-stage renal disease. Volume progression in autoso-mal dominant polycystic kidney disease: the major factor determining clinical outcomes. Magnetic resonan...

CONTEXT Polycystic disease is a rare disorder, which most commonly manifests in the kidney and liver. Recently an increased risk for pancreatic malignancies in subsets of patients with polycystic disease has been reported. CASE REPORT We report a patient with polycystic liver and kidney disease who successfully underwent a Whipple's procedure for pancreatic adenocarcinoma. CONCLUSION Althou...

For quite some time the field of polycystic kidney disease has led a life at the fringe of kidney research, but with the cloning of the PKD1 and many other genes this situation has dramatically changed. Polycystic kidney disease often is a syndromic disease affecting a variety of organs in addition to the kidney. Most of the proteins involved in polycystic kidney disease have been localized to ...

Increased cell proliferation and fluid secretion, probably driven by alterations in intracellular calcium homeostasis and cyclic adenosine 3,5-phosphate, play an important role in the development and progression of polycystic kidney disease. Hormone receptors that affect cyclic adenosine monophosphate and are preferentially expressed in affected tissues are logical treatment targets. There is a...

Acquired polycystic kidney disease occurs as one of the sequelae of chronic haemodialysis. Spontaneous perirenal haemorrhage of acquired polycystic kidney disease in a patient on chronic haemodialysis is an uncommon clinical entity [1–4], and bilateral perirenal haemorrhage in these patients is rare [5]. This report describes one case of bilateral perirenal haemorrhage in a haemodialysis patien...

OBJECTIVE: To study the feasibility of making an early diagnosis of adult polycystic kidney disease by using genetic linkage analysis in Hong Kong. DESIGN: Genetic linkage study. SETTING: University teaching hospital, Hong Kong. PARTICIPANTS: Six members of a Chinese family with a history of adult polycystic kidney disease. MAIN OUTCOME MEASURES: The inheritance pattern of adult polycystic kidn...

Alterations in intracellular calcium homeostasis and cyclic adenosine 3',5'-phosphate likely underlie the increased cell proliferation and fluid secretion in polycystic kidney disease. Hormone receptors that affect cyclic adenosine 3',5'-phosphate and are preferentially expressed in affected tissues are logical treatment targets. There is a sound rationale for considering the arginine vasopress...

The genetic locus for autosomal dominant adult polycystic kidney disease was recently assigned to chromosome 16 by the finding of genetic linkage to the alpha globin gene cluster. Further study showed that the phosphoglycolate phosphatase locus is also closely linked to both the locus for adult polycystic kidney disease and the alpha globin gene cluster. These findings have important implicatio...