In insects, the ecdysteroids act to transform the CNS from its larval to its adult form. A key gene in this response is the ecdysone receptor (EcR), which has been shown in Drosophila to code for 3 protein isoforms. Two of these isoforms, EcR-A and EcR-B1, are prominently expressed in the CNS and we have used isoform-specific antibodies to examine their fluctuations through postembryonic life. ...

The ecdysone receptor (EcR) belongs to the nuclear-hormone receptor superfamily that functions as a ligand-activated transcription factor. The EcR plays an essential role in arthropod development and reproduction. While the molecular basis for the interaction between the EcR and its ligand has been well investigated in insects, information on the EcR function in crustaceans is limited. In the p...

In D. melanogaster a pulse of the steroid hormone ecdysone triggers the larval-to-adult metamorphosis, a complex process in which this hormone induces imaginal t issues to generate adult structures and larval tissues to degenerate. We show that the EcR gene encodes three ecdysone receptor isoforms (EcR-A, EcR-81 , and EcR-B2) that have common DNAand hormone-binding domains but different N-termi...

Advancement of nuclear physics and high power heavy ion accelerator is always a driving force for persistent development of highly charged ECR ion source. Increasing demands for more intense and higher charge state heavy ion beams have dramatically promoted development of ECR ion source technology and physics. This talk provides an overview of intense highly charged superconducting ECR ion sour...

Ecdysteroids, primarily 20-hydroxyecdysone (20E), play a central role in the growth of arthropods. Molecular target of the ecdysteroids is known as a receptor complex composed of ecdysone receptor (EcR) and ultraspiracle (USP) protein. It is important to clarify the expression profile of EcR/USP in crustacean for understanding the endocrine disrupting effects of environmental xenobiotics on cru...

OBJECTIVE Equivalent cross-relaxation rate (ECR) imaging is an MRI technique used to evaluate quantitatively a change in the protein-water interaction. We aimed to evaluate retrospectively the usefulness of ECR imaging for the histologic classification of malignant lymphoma (ML). MATERIALS AND METHODS Institutional Review Board approval was obtained and all patients provided informed consent....

Next-generation heavy ion beam accelerators require a great variety of high charge state ions with an order of magnitude higher beam intensity than is currently routinely available. Driven by this increasing demand for high performance ECR ion sources and enabled by advances in superconducting magnet technology, third generation superconducting (SC) ECR ion sources have been developed world-wid...

The insect hormone 20-hydroxy-ecdysone (20E) peaks at different stages during the life cycle. The hormone signal is commonly transmitted by a nuclear receptor consisting of the ecdysone receptor (EcR) and Ultraspiracle (Usp, orthologous to vertebrate RXR). EcR:Usp then initiate the expression of a series of gene regulators that help mediate biological responses to the hormone. Here, we investig...

In Drosophila melanogaster, fruitless (fru) encodes male-specific transcription factors (FRU(M); encoded by fru P1) required for courtship behaviors (reviewed in). However, downstream effectors of FRU(M) throughout development are largely unknown. During metamorphosis the nervous system is remodeled for adult function, the timing of which is coordinated by the steroid hormone 20-hydroxyecdysone...