Immunization is an important cost effective strategy for child survival(l,2). With the inclusion of heat labile oral polio and measles vaccine in the Universal Immunization Programme, maintenance of cold chain is of paramount importance(3). Inadequate management of cold chain may reduce the potency of the oral polio vaccine to almost zero. In India 15 to 30% cases of poliomyelitis, occur in chi...

(WHO) is contemplating discontinuing the use of an oral polio vaccine that’s been linked to ongoing outbreaks of the virus in the developing world. WHO is weighing the possibility of using a different formulation of the vaccine, but maintains that patchy implementation of immunization programs, not the vaccine itself, is to blame for the outbreaks. Since 2000, some two billion children have rec...

The development of new low cost inactivated polio virus based vaccines (IPV) is a high priority, and will be required to eradicate polio. In addition, such a vaccine constitutes the only realistic polio vaccine in the post-eradication era. One way to reduce the cost of a vaccine is to increase immunogenicity by use of adjuvants. The CAF01 adjuvant has previously been shown to be a safe and pote...

Global polio eradication is closer than ever. Replacement of the live attenuated oral poliovirus vaccine (OPV) by inactivated poliovirus vaccine (IPV) is recommended to achieve complete eradication. Limited global production capacity and relatively high IPV costs compared to OPV spur the need for improved polio vaccines. The target product profile of these vaccines includes not only dose sparin...

India was certified polio free on 27 March 2014. Supplementary immunization activities, in the form of national immunization days, is one of the core strategies for eradication, where oral polio vaccine is administered to children aged under 5 years throughout the country. Oral polio vaccine is heat sensitive and requires maintenance of a stringent cold chain. Therefore, vaccine carriers with i...

The present article reports a case involving an immunocompetent, previously well child who, despite two previous doses of inactivated poliovirus vaccine, developed severe flaccid paralysis consistent with polio after receiving oral polio vaccine.

The book, The river, is based on assumptions and not facts. Oral polio vaccine was produced entirely in rhesus monkey kidney cell cultures. Allegations that it was produced in chimpanzee kidneys at the Wistar Institute in Philadelphia or, alternatively, that the vaccine was made in the then Belgian Congo in chimpanzee kidney has no basis in fact. As the only witness to the historical events lea...

OBJECTIVES Eradication and control of childhood diseases through immunization can only work if parents allow their children to be vaccinated. To learn about social network factors associated with polio vaccine hesitancy, we investigated social and spatial clustering of households by their vaccine acceptance status in Malegaon, India, an area known for vaccine refusal and repeated detection of p...

Pakistan is one of the two endemic countries for polio, reporting co-circulation WPV1 and cVDPV2. classified by International Health Regulations (IHR) as a state infected with Wild Poliovirus type 1 (WPV1) circulating Vaccine derived poliovirus 2 (cVDPV2) potential risk international spread. We describe an ongoing outbreak in North Waziristan district southern Khyber Pakhtunkhwa (KP) province l...