OBJECTIVE To investigate whether estrogen exposures are associated with lower risks of age-related macular degeneration (AMD). METHODS Postmenopausal hormone (PMH) use, past use of oral contraceptives (OCs), ages at menarche and menopause, and parity were assessed among 74,996 postmenopausal women. Over 22 years, cases of early (n = 554) and neovascular (n = 334) AMD with a visual acuity of 2...

We propose an improved proposal distribution in the Particle Metropolis-Hastings (PMH) algorithm for Bayesian parameter inference in nonlinear state space models. This proposal incorporates second-order information about the parameter posterior distribution, which can be extracted from the particle filter already used within the PMH algorithm. The added information makes the proposal scale-inva...

BACKGROUND Positive mental health (PMH) is much more than the absence of mental illnesses. For example, PMH explains that to be happy or resilient can drive us to live a full life, giving us a perception of well-being and robustness against everyday problems. Moreover, PMH can help people to avoid risky behaviours like tobacco consumption (TC). Our hypothesis was that PMH is negatively associat...

PURPOSE Nd:YAG laser membranotomy is considered a safe treatment of premacular hemorrhage (PMH) in adult patients, enabling rapid enhancement of visual functions. For children, however, pars plana vitrectomy (PPV) performed under general anesthesia has been the accepted treatment. In this report, the authors describe Nd:YAG laser membranotomy (LM) in two children with PMH complicated by hematol...

Psychiatric nurses in the United States (US) stand at the edge of a changing mental health care landscape. Federal initiatives are moving into place; ones that aim to increase access to care, place a greater emphasis on prevention and wellness, and position recovery as the focus of mental health treatment. The Psychiatric Mental Health (PMH) specialty is at a pivotal moment of choice: it can or...

The authors developed a scale for positive mental health (PMH), which encompasses positive state of mind and positive functioning. The existing tools are inadequate to measure the construct, especially in a community where the self-statement format of a scale is difficult to internalize. The authors constructed a tool from an initial item pool with the help of experts and validated it in a samp...

Menopause is associated with increased urinary calcium excretion, which could increase the risk for the development of calcium-containing kidney stones. However, it is unknown whether menopause and postmenopausal hormone (PMH) use are independent risk factors for incident kidney stone disease in women. Data from 91,731 female Nurses' Health Study participants who provided information on diet, m...

As an important target for the development of novel antibiotics, UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) has been widely studied. Pyridone methylsulfone hydroxamate (PMH) compounds can effectively inhibit the catalytic activity of LpxC. In this work, the three-dimensional quantitative structure-activity relationships of PMH inhibitors were explored and models with ...

Melatonin transduces the effect of day length on LH secretion by acting on the hypothalamus. However, the precise hypothalamic site is unknown. Two studies were undertaken to clarify where melatonin acts in the hypothalamus. Using autoradiographic methods, the hypothalami of 5 ewes were screened to determine whether specific regional densities in melatonin binding existed. A higher density of b...