Phospholemman (PLM), a member of the FXYD family of regulators of ion transport, is a major sarcolemmal substrate for protein kinases A and C in cardiac and skeletal muscle. In the heart, PLM co-localizes and co-immunoprecipitates with Na(+)-K(+)-ATPase, Na(+)/Ca(2+) exchanger, and L-type Ca(2+) channel. Functionally, when phosphorylated at serine(68), PLM stimulates Na(+)-K(+)-ATPase but inhib...

Candida albicans is a common, harmless yeast in the human digestive tract that also causes severe systemic fungal infection in hospitalized patients. Its cell-wall surface displays a unique glycolipid called phospholipomannan (PLM). The ability of PLM to stimulate tumor necrosis factor (TNF)-alpha production by J774 mouse cells correlates with the activation of nuclear factor (NF)-kappaB. We ex...

The benefits of Product Lifecycle Management (PLM) have been noted for improving business, creating collaboration, and reducing energy and time by making transcendent decisions through the process of product life cycle. This work aims to propose a PLM Components Maturity Assessment (PCMA) model to gain comprehensive maturity results and reduce the complexity in obtaining maturity scores. Accord...

BACKGROUND Phospholemman (PLM) is an important phosphorylation substrate for protein kinases A and C in the heart. Until now, the association between PLM phosphorylation status and L-type calcium channels (LTCCs) gating has not been fully understood. We investigated the kinetics of LTCCs in HEK 293T cells expressing phosphomimetic or nonphosphorylatable PLM mutants. METHODS The LTCCs gating w...

The primary trigger to periodic limb movement (PLM) during sleep is still unknown. Its association with the restless legs syndrome (RLS) is established in humans and was reported in spinal cord injury (SCI) patients classified by the American Spinal Injury Association (ASIA) as A. Its pathogenesis has not been completely unraveled, though recent advances might enhance our knowledge about those ...

PLM is today a reality for mechanical SMEs. Some companies implement PLM systems very well but others have more difficulties. This paper aims to explain why some SMEs do not success to integrated PLM systems analyzing the needs of mechanical SMEs, the processes to implement to respond to those needs and the actual PLM software functionalities. The proposition of a typology of those companies an...

Phoslactomycins (PLMs) and related leustroducsins (LSNs) have been isolated from a variety of bacteria based on antifungal, anticancer, and other biological assays. Streptomyces sp. strain HK 803 produces five PLM analogs (PLM A and PLMs C to F) in which the C-18 hydroxyl substituent is esterified with a range of branched, short-alkyl-chain carboxylic acids. The proposed pathway intermediate, P...

Zhang XQ, Wang J, Carl LL, Song J, Ahlers BA, Cheung JY. Phospholemman regulates cardiac Na /Ca exchanger by interacting with the exchanger’s proximal linker domain. Am J Physiol Cell Physiol 296: C911–C921, 2009. First published January 21, 2009; doi:10.1152/ajpcell.00196.2008.—Phospholemman (PLM) belongs to the FXYD family of small ion transport regulators. When phosphorylated at Ser, PLM inh...

The concept (and implementation) of Product Lifecycle Management (PLM) has drawn much attention in both industry and academia. This paper investigates the scope of PLM systems, presents different types of PLM architecture and identifies an appropriate definition of PLM for a Network-Centric Manufacturing paradigm with a specific focus on small manufacturing enterprises. Research issues of PLM s...

We present a new kind of pattern classifier, the Polynomial Learning Machine (PLM). The PLM is derived, and its construction detailed. We compare the performance of the PLM to that of the Support Vector Machine (SVM) in classifying binary-classed data sets, and find that the PLM consistently trains and tests in a shorter time than the SVM while maintaining comparable classification accuracy; in...