The chemistry of complexes with diatomic chalcogen ligands has attracted much attention due to their unique structure, biological interest, potential for hydrogen-transfer catalysis, and synthetic utility as a precursor of new metal cluster complexes. However, since sulfur and selenium ligands have a strong propensity for bridging metal atoms, it is often difficult to prepare their mononuclear ...

The transport system of platinum-based anticancer agents is crucial for drug sensitivity. Increasing evidence indicates that the copper transport system is also involved in the cellular influx and efflux of platinum drugs. The copper chaperone Atox1 has been shown to bind to cisplatin in vitro and in cells. Previous results reveal that copper binding promotes the reaction between Atox1 and cisp...

Dinuclear structure of platinum( ii ) complexes favours thermally activated delayed fluorescence (TADF).

Dichloro-1,2-diaminocyclohexane (DACH):platinum(II), the prototype DACH:platinum complex, had good antitumor activity, was not cross-resistant with cis-dichlorodiammineplatinum(II) (DDP), but was, unfortunately, virtually insoluble in water and was, therefore, not evaluated clinically. This paper summarizes some of the chemical and biological attributes of a series of cis-bisascorbato-DACH:plat...

Symmetrical bis-aryl platinum complexes (DPPF)Pt(C(6)H(4)-4-R)(2) (R = NMe(2), OMe, CH(3), H, Cl, CF(3)) and electronically unsymmetrical bis-aryl platinum complexes (DPPF)Pt(C(6)H(4)-4-R)(C(6)H(4)-4-X) (R = CH(3), X = NMe(2), OMe, H, Cl, F, CF(3); R = OMe, X = NMe(2), H, Cl, F, CF(3); R = CF(3), X = H, Cl, NMe(2); and R = NMe(2), X = H, Cl) were prepared, and the rates of reductive elimination...

PURPOSE As novel therapeutic agents relevant to colon cancer therapy are explored continuously, we tested 4 R2edda-type ligand precursors O,O'-dialkyl esters of (S,S)-ethylenediamine-N,N'-di-2-(4-methyl)pentanoic acid (L1.2HCl-L4.2HCl) and corresponding palladium(II) and platinum(II) complexes against the human colon cancer cell lines CaCo-2, SW480 and HCT116. METHODS The effects of the teste...

In the present study two nanocrystalline apatites have been investigated as bone-specific drug delivery devices to be used for treatment of bone tumors either by local implantation or by injection. In order to assess how the Ca/P ratio can influence the adsorption and release of anticancer platinum-bisphosphonate complexes, two kinds of apatite nanocrystals having different Ca/P ratios but simi...

Platinum(II) complexes bearing acetylide ligands containing nucleobase motifs are prepared and their impact on human topoisomerase II (TopoII) is evaluated. Both platinum(II) complexes [Pt(II)(C^N^N)(C≡CCH₂R)] (1a-c) and [Pt(II)(tBu₃terpy)(C≡CCH₂R)](+) (2a-c) (C^N^N=6-phenyl-2,2'-bipyridyl, tBu₃terpy=4,4',4''-tri-tert-butyl-2,2':6',2''-terpyridyl, and R=(a) adenine, (b) thymine, and (c) 2-amino...

A unique class of neutral cyclometalated platinum(ii) complexes with π-bonded benzenedithiolate are reported including two X-ray molecular structures. To the best of our knowledge these are the first structures to be reported for cyclometalated platinum complexes with a benzenedithiolate ligand. All of the complexes are luminescent in fluid solution at room temperature and in frozen solvent gla...

The development of resistance is one of the major limitations for the use of platinum (Pt) complexes in cancer chemotherapy. As reduced cellular uptake is a well-known resistance mechanism of cisplatin we explored the potential to overcome resistance in cisplatin-resistant A2780 ovarian carcinoma cells by means of macromolecular prodrugs exploiting endocytosis as alternative uptake mechanism. T...