background: aurones are naturally occurring compounds that belong to flavenoids family and have antiplasmodial effects. this study investigated some new aurones derivatives against chloroquine sensitive plasmodium falciparum. here we report the synthesis , in vitro antiplasmodial activity and cytotoxic evaluation of 11 compound from derivatives of (z)-2- benzylidene-4, 6-dimethoxybenzofuran-3(2...

Quinine is the best studied drug for treating severe malaria in very young children. Quinine may be administered in pregnancy and, at therapeutic doses, malformations have not been reported. Some strains of quinine from Southeast Asia and South America have become resistant. Quinine is the treatment of choice for the drug-resistant severe Plasmodium falciparum. The antimalarial mechanism of qui...

anopheles stephensi is one of the main vectors of malaria in the world including south of iran. three geographical populations for an. stephensi have been defined, based on egg morphology. the aim of the current study is determining the ability of different geographical populations of an. stephensi in the transmission of plasmodium berghei using anka strain of this parasite. four geographical p...

penfluridol, a neuroleptic drug, considerably reversed halofantrine resistance in t9.96hf halofantrine resistant strain of plasmodium falicparum (originally chloroquine sensitive parasites), but not in k1hf halofantrine resistant strain (originally chloroquine resistant parasites)

background: the emergence and spread of chloroquine resistant plasmodium falciparum in the world stimulated some investigators to consider different aspects of chloroquine resistance in human and rodent plasmodia . using animal plasmo­dia , particularly primate and rodent plasmodia can be useful model for human plasmodia studies. in this study we have tried to consider and compare the sequence ...

Fourteen plant species collected in Iran and selected mainly on the basis of their antimicrobial and/or antifungal activities were evaluated for in vitro antiplasmodial and cytotoxic effects in a study designed to screen plant extracts with selective activity against Plasmodium falciparum. The methanol extracts of nine of the species tested exhibit activity against Plasmodium falciparum (MIC va...