introduction: depression is one of the most frequent psychiatric disorders in the world with occurs with higher incidence in women. in the present study, the effect of water-alcoholic extract of papaver rhoeas l. on forced swimming test (fst) in swiss-webster mice were examined. methods: we used swiss-webster mice (20-25 g) to execute fst on them. the plant extract (1, 10, 30, and 100 mg/kg) wa...

Calorie restriction of young male rats increases plasma prolactin, decreases luteinizing hormone (LH) and testosterone, and disrupts their 24 h secretory pattern. To study whether this could be the consequence of stress, we examined the 24 h variations of plasma adrenocorticotropic hormone (ACTH) corticosterone, growth hormone (GH), leptin, and adrenal corticosterone. Rats were submitted to a c...

Corticosterone has been demonstrated in human adrenal perfusates (l), and in adrenal venous blood obtained by cannulation of the adrenal vein immediately prior to adrenalectomy (2). Several investigators (Morris and Williams (3), Bush and Sandberg (4), Weichselbaum and Margraf (5), and Sweat (1)) have reported the presence of corticosterone or “corticosterone-like” substances in the peripheral ...

OBJECTIVE In humans, the glucocorticoid corticosterone circulates in blood at 10-20-fold lower levels than cortisol, but is found in higher relative amounts in postmortem brain samples. Access of cortisol and corticosterone to the central nervous system may not be equal. Additionally, the relative affinities for the glucocorticoid and mineralocorticoid receptors differ, such that corticosterone...

introduction: the brain glutamate neurotransmitter system and its nmda receptors in the nucleus accumbens play an important role in the incidence of the phenomena of sensitivity and addiction. the present study examined the inhibitory effect of glutamate nmda receptors in the nucleus accumbens in response to chronic stress. methods: after the unilateral and bilateral cannula placement in the nu...

Activity of the hypothalamic-pituitary-adrenal axis is characterized by a diurnal rhythm with an AM nadir and PM peak. Splanchnic nerve transection disrupts the diurnal rhythm in plasma corticosterone; however, there is a controversy as to whether the nerve-mediated effect is 1) via inhibition in the AM vs. excitation in the PM, or 2) involves changes in adrenal sensitivity to ACTH. The present...

Abstract* Introduction: Visual system have been considered as among important sensory system in animals’ life span and their survival is closely related to normal visual system functioning. Since in previous studies it have been revealed that morphine consumption during pregnancy could lead to defect and delay in nervous system development in the embryos, in the present study, changes induc...

The chronic exposure to ELF-EMF (extremely-low frequency electromagnetic field) has been shown as an effective factor at biological systems. In order to determine the possible effects of whole-body exposure to EMF on plasma levels of testosterones and corticosterone, weight gain and testicular gene expression of Gstt1 of male rats, the present study was performed by the following procedure: thi...

The suprachiasmatic nucleus (SCN) is required for the daily rhythm of plasma glucocorticoids; however, the independent contributions from oscillators within the different subregions of the SCN to the glucocorticoid rhythm remain unclear. Here, we use genetically and neurologically intact, forced desynchronized rats to test the hypothesis that the daily rhythm of the glucocorticoid, corticostero...

the chronic exposure to elf-emf (extremely-low frequency electromagnetic field) has been shown as an effective factor at biological systems. in order to determine the possible effects of whole-body exposure to emf on plasma levels of testosterones and corticosterone, weight gain and testicular gene expression of gstt1 of male rats, the present study was performed by the following procedure: thi...