In this paper, we study the Plancherel measure of a class of non-connected nilpotent groups which is of special interest in Gabor theory. Let G be a time-frequency group. That is G = ⟨ Tk,Ml : k ∈ Z, l ∈ BZ ⟩ , where Tk, Ml are translations and modulations operators acting in L(R), and B is a non-singular matrix. We compute the Plancherel measure of the left regular representation of G which is...