In this issue of Neuron, Kornblith et al. (2013) identify two regions in macaque occipitotemporal cortex that encode both spatial and nonspatial aspects of visual scenes and might be the homolog of the human parahippocampal place area.

The human brain has hundreds of billions neurons and at least 7 million dendrites have been hypothesized to exist for each neuron, with over 100 trillion neuron–neuron, neuron–muscle, neuron–endocrine cell synapses [...]

Recent studies have shown that place cells in the hippocampal CA1 region fire in a sequence sensitive manner. In this study we tested if hippocampal CA3 and CA1 regions can give rise to the sequence sensitivity. We used a two-layer CA3-CA1 hippocampal model that consisted of Hodgkin-Huxley style neuron models. Sequential input signals that mimicked signals projected from the entorhinal cortex g...

In the brain, information is encoded by the firing patterns of neuronal ensembles and the strength of synaptic connections between individual neurons. We report here that representation of the environment by "place" cells is altered by changing synaptic weights within hippocampal networks. Long-term potentiation (LTP) of intrinsic hippocampal pathways abolished existing place fields, created ne...

Multiple muscle agonists and antagonists acting for all the joint movements in the upper and lower limb exist. This redundancy of motor control is very valuable in normal physiology, but when a central nervous system injury with resulting upper motor neuron syndrome takes place, the source of the functional impairment may be difficult to localize. In this paper we discuss the use of gait and mo...

apoptosis plays an important role in many pathological processes of the central nervous system. the neuroprotective effect of periodic fasting (pf) in contrast to severe fasting or starvation has been suggested. however, these beneficial effects seem to depend on the type and duration of the used feeding protocol. this study was designed to evaluate the effects of different pf protocols on the ...

Today, concepts such as place attachment, sense of place, meaning of place, place identity, has devoted many studies In literature of architecture and urban design particularly in the field of environmental psychology. It is obvious that in all these concepts, various aspects of interaction between human and place and the impact that places have on people has been presented. This paper defines ...

A place cell system is developed that is able to provide robust localisation using simple sonar information only. The system uses egocentric view cells, based on the Adaptive Response Function Neuron, as sensory input to correct for path integration errors. The major advantage of this system is that place field centres are fixed prior to training, allowing downstream navigational systems to mak...

Hippocampal place cells are active when the rat is at certain locations. The sequence of these active place cells is known to be rapidly replayed during sharp-wave-ripple events in the EEG. In this issue of Neuron, a study by Gupta et al. challenges previous notions that the replayed trajectories are solely a passive echo of past episodes. Rather, replay might also be an active process construc...

Introduction: The aim of this study was evaluate the ability of notochord to induce neural induction and/or differentiation of mouse embryonic stem cell to neuron and motor neuron, respectively. Methods: In order to produce embryoid bodies, ES cells line Royan B1 were grown in suspension in the absence of LIF for 4 days. EBs were divided into 4 groups. EBs in group 1 & 2 were further cultur...