Sir, We read with interest the article by Pandhi et al.,[1] who evaluated the efficacy of azithromycin in pityriasis rosea (PR) and we are not entirely surprised by its failure. In fact, an increasing number of studies using valid methodology have focused on the role of systemic infection with human herpes virus (HHV) 6 and/or 7 as the cause of pityriasis rosea.[2] Hence, azithromycin had only ...

Background: Pityriasis rosea is an acute, inflammatory and self-limited disease, which is characterized by a primary scaly plaque (Herald patch) followed by a generalized, symmetrical papulosqumous eruption (Mostly on trunk and proximal extremities). Objective: To determine the efficacy of erythromycin in the treatment of patients with pityriasis rosea. Patients and Methods: In this doubl...

Background: Pityriasis rosea is an inflammatory skin disorder with a known response to erythromycin. Considering similarities between erythromycin and azithromycin and lesser adverse effects of the latter, in a pilot study, we gave azithromycin to seven patients with pityriasis rosea and observed a noticeable improvement. The aim of this study was to evaluate the efficacy of azithromycin ...

One hundred and twenty-six cases of pityriasis rosea seen over two years in north Staffordshire were analysed for clustering in time and space. A statistically significant degree of clustering was found; this was evident among female patients considered separately but not among male patients. The incidence of the condition was higher in patients working in, or attending, educational establishme...

T HE Medical Research Council's investigation into pityriasis rosea in 1959 has already been published (Proc. roy. Soc. Med., 55, 556). This second investigation, based on a very simple questionnaire, has produced some additional information, but has not altogether solved the question put, namely "What is the cause of this disease?" Much interest was shown. In 1964, 180 observers notified 531 c...

A 23-year-old woman came to our outpatient clinic with a two-weeks history of pruritic reddish lesions on her armpits and groins. Her past medical history was consistent with neurofibromatosis type 1 (NF-1), for which she was under routine follow-up. Upon dermatological examination we observed multiple erythematous to violaceous coalescent and infiltrative plaques with central clearing which we...

Pityriasis rosea is a distinct papulosquamous skin eruption that has been attributed to viral reactivation, certain drug exposures or rarely, vaccination. Herein, we reported a clinicopathlogically typical case of pityriasis rosea that developed after the H1N1 vaccination. With a global H1N1 vaccination program against the pandemic H1N1 influenza, patients should be apprised of the possibility ...