We investigated the effects of piperitenone oxide (PO), a major constituent of the essential oil of Mentha x villosa, on the guinea pig ileum. PO (30 to 740 micrograms/ml) relaxed basal tonus without significantly altering the resting membrane potential. In addition, PO relaxed preparations precontracted with either 60 mM K+ or 5 mM tetraethylammonium in a concentration-dependent manner. At con...

Studying the biosynthesis of oil compounds in Perilla will help to elucidate regulatory systems for secondary metabolites and reaction mechanisms for natural product synthesis. In this study, two types of alcohol dehydrogenases, isopiperitenol dehydrogenases 1 and 2 (ISPD1 and ISPD2), which are thought to participate the oxidation of isopiperitenol in the biosynthesis of perilla, were isolated ...

background & aim: lamiaceae is one of the most important families of plants with global transmittal. the family is divided to two major groups: lamioideae and nepetoideae. mentha l. genus has high genetic variation because of different ploidy levels and interspecific interspecific hybridization thus that is possible to select genotypes with excelsior traits as essence content. the genus inc...

Essential oils from mint plants, including peppermint and pennyroyal oils, are used at low levels as flavoring agents in various foods and beverages. Pulegone is a component of these oils. In a 2-year bioassay, oral administration of pulegone slightly increased the urothelial tumor incidence in female rats. We hypothesized that its mode of action (MOA) involved urothelial cytotoxicity and incre...

Background & Aim: Lamiaceae is one of the most important families of plants with global transmittal. The family is divided to two major groups: Lamioideae and Nepetoideae. Mentha L. genus has high genetic variation because of different ploidy levels and interspecific interspecific hybridization thus that is possible to select genotypes with excelsior traits as essence content. The genu...

Background & Aim: Lamiaceae is one of the most important families of plants with global transmittal. The family is divided to two major groups: Lamioideae and Nepetoideae. Mentha L. genus has high genetic variation because of different ploidy levels and interspecific interspecific hybridization thus that is possible to select genotypes with excelsior traits as essence content. The genu...

The study was aimed to investigate essential oil chemical composition (gas chromatography/flame ionization detection [GC-FID] and gas chromatography/mass spectrometry [GC-MS]) and antioxidant (1,1-diphenyl-2-picrylhydrazyl free radical (DPPH) and 2,2'-azinobis-3-ethylbenzothiazoline-6-sulphonate [ABTS] assays) and antimicrobial (Gram-positive and Gram-negative bacteria, fungi, and yeast) activi...