The U.S. pharmaceutical industry plays a vital role in shaping the face of American healthcare. As an industry rooted in innovation, its continued evolution is inherent. With major patent expirations looming and thin product pipelines, the industry now must consider new directions to maintain growth and stability. Follow-on biologics, derived from living organisms and marketed after the patent ...

Predictions of the gas temperature and pressure profiles are vital to the design and operation of gas transmission lines. Available analytical methods for the calculation of these profiles are evaluated and a numerical framework for the rigorous calculation has been developed. The predictions from both the analytical and numerical procedure have been compared to field data from the Iranian Gas ...

Developing sophisticated NLP pipelines composed of multiple processing tools and components available through different providers may pose a challenge in terms of their interoperability. The Unstructured Information Management Architecture (UIMA) is an industry standard whose aim is to ensure such interoperability by defining common data structures and interfaces. The architecture has been gain...

nowadays, compressible flow transmission pipelines are used in many industrial processes. pipelines in chemical processes, gas turbine power plants, natural gas transmission lines, and high pressure steam transmission pipelines are some industrial examples. therefore, learning the manner of treatment of a transient compressible fluid flow in pipelines with junctions and branches is important. i...

For model-driven engineering (MDE) to become more Agile, the community needs embrace development and operations (DevOps) practices. One of core practices DevOps is use pipelines enable CI/CD make teams Agile break down barriers between with faster deployments. Current MDE tooling not designed at its participate in pipelines. Consequently this makes adoption industry difficult. In article, we co...

Sensornets promise to extend automated monitoring and control into industrial processes. In spite of great progress made in sensornet design, deployment and operational cost impedes use of sensornet in many real-word scenarios—these challenges are so great that industries often continue with infrequent, manual observations over automation, even for key business processes. In this paper we propo...

In many new product development (NPD) situations, the development process is characterized by uncertainty, and no single development approach (e.g., a particular technological version) will necessarily lead to a successful product. In order to increase the likelihood of having at least one successful product at the end of the NPD process, managers may choose to fund simultaneously multiple appr...

determination of allowable free span length plays a crucial role in design of offshore pipelines. the seabed intervention cost and safety of an offshore pipelines project are largely influenced by pipelines free spanning during the project life time. different criteria are proposed by both the current designing guidelines and researchers there is however lack of comprehensive assessment of inde...

Geological conditions along long distance pipelines are complex. In consideration of differences in elevation and terrain obstacles, long distance pipelines are commonly laid through tunnels. Oil and gas pipelines are often laid side by side to reduce construction costs and minimize geological impact. The layout and construction of parallel oil and gas pipelines are more complex than those of s...