BACKGROUND Preeclampsia (PE) is a pregnancy-related vascular disorder which is the leading cause of maternal morbidity and mortality. We sought to identify novel serological protein markers to diagnose PE with a multi-'omics' based discovery approach. METHODS Seven previous placental expression studies were combined for a multiplex analysis, and in parallel, two-dimensional gel electrophoresi...

Systemic lupus erythematosus (SLE) is an autoimmune disease of multifactorial pathoaetiology. Different organs and blood vessels may be affected by chronic inflammation. A direct cause of the disease has not yet been found, so research is being carried out to this effect. The role of the recently identified helper T lymphocyte CD4+, described as Th17, and its dependent cytokines have been of pa...

Results The mean serum level of sFlt-1 and sEng in women with preeclampsia was significantly higher than normal pregnancy. But the mean serum level of PIGF had no signifi cant difference between two groups. The cut-off values of sFlt-1 and sEng showing differential signifi cance were 26.3 ng/mL and 21.1 ng/mL each. Then the sensitivity, specifi city, positive predictive value, negative predicti...

Background. To assess the ability of mid-trimester sFlt-1/PlGF ratio for prediction of preeclampsia in two different Arabic populations. Methods. This study measured levels of sFlt-1, PlGF, and sFlt-1/PlGF ratio at midtrimester in 83 patients who developed preeclampsia with contemporary 250 matched controls. Results. Women subsequently developed preeclampsia had significantly lower PlGF levels ...

BACKGROUND Type I insulin-like growth factor receptor (IGF-IR) tyrosine kinase induces significant oncogenic effects. Strategies to block IGF-IR signaling are being tested in clinical trials that include patients with aggressive solid malignancies. Mantle cell lymphoma is a B-cell neoplasm with poor prognosis and a tendency to develop resistance. The expression and potential significance of IGF...

Purpose: to study the composition and content of proinflammatory cytokines, chemoattractant mediators, vascular growth factors in blood serum (SB) lacrimal fluid (LF) patients with KPHR. Materials methods. A total 106 postinflammatory corneal spots turbid transplant were examined. The control group consisted 20 practically healthy donors. Cytokines: IL-2, IL-18, MCP-1 / CCL2, MIP-1β CCL4, RANTE...