Objective(s): Eupafolin, a major active component of Eupatorium perfoliatum L., has anti-inflammatory and anti-oxidant properties. Lipopolysaccharide (LPS) is responsible for myocardial depression. A line of evidences revealed that LPS induces autophagy in cardiomyocytes injury. This study aims to evaluate the effects of eupafolin on LPS-induced cardiomyocyte autophagy...

Objective(s): The current study was aimed to investigate the effect of morpholin-4-ium 4 methoxyphenyl (morpholino) phosphinodithioate (GYY4137) on ipsilateral epididymis injury in a rat model of experimental varicocele (VC).Materials and Methods: Sixty Wistar rats were randomly assigned to sham, sham plus GYY4137, VC and VC plus GYY4137...

Purpose: To investigate the effect of Qibai Pingfei capsules (QBPF) medicated serum on apoptosis rat pulmonary artery smooth muscle cells (PASMC) in hypoxic rats, and to determine relationship between that PI3K/Akt/mitochondrial pathway.Methods: Rat PASMCs were isolated, cultured, optimal time concentration QBPF determined by CCK-8 method. Hypoxic rats treated with QBPF, + LY294002, or SC79. Ap...

conclusions in conclusion, ctp-hbcag18-27-tapasin could reduce apoptosis of cd8+ t cells, increase the percentages of ifn-γ+ cd8α+ t cells, and elicit cell-mediated immunity in hla-a2 transgenic mice; these processes were associated with activation of the pi3k/akt signaling pathway. results the results showed that ctp-hbcag18-27-tapasin significantly increased the percentages of ifn-γ+ cd8α+ t ...

background: acute lymphoblastic leukemia (all), the most common childhood cancer with a peak incidence in children from 2-5 years old, might be associated with poor prognosis and resistance to therapy in specific cytogenetic backgrounds. foxo3a, a member of the forkhead class 'o' (foxo) transcription factors, is a main downstream target of pi3k/akt pathway which regulates different variety of b...

the lung cancer is one of the most dangerous cancers and is also the leading cause of cancer death worldwide, accounting for about 1.3 million deaths annually. however in clinical practice, lung cancer therapies commonly do with chemotherapy, although it is hard because the lung cancer may progress to metastasis stage. the metastasis of lung cancer is highly dependent of expression of matrix me...

Objective(s): JiangTangXiaoKe (JTXK) granule, a Chinese traditional herbal formula, has been clinically used and demonstrated to be beneficial in controlling high glucose and to relieve the symptoms of  Type 2 diabetes mellitus patients for decades. In this study, we explored how loganin, one of the components in JTXK granule, mediated the anti-diabetic effect.Materials and Methods: We generate...

This study aims to explore the cytotoxic, apoptotic and autophagic effects of thymoquinone on human acute myeloid leukemia. The cytotoxic were determined with 3-(4, 5-dimethylthiazol-2-yl)-2 5-diphenyltetrazolium bromide (MTT) tests. B-cell lymphoma 2 associated X protein (Bax), (Bcl-2), caspase 3, mammalian target rapamycin (mTOR), phosphatidylinositol-3-kinase (PI3K), kinase B (AKT) gene expr...

Background Liver cancer is a common threat to human health. Schizandrin A (SA) has certain therapeutic effect on liver cancer, but its related mechanism of action not clear. Elucidating this great significance for the development drugs target cancer. Objective The objective study and SA Methods potential targets in treatment were screened based network pharmacology, core further by protein inte...